GCK
Gene Ontology Biological Process
- NADP metabolic process [IMP]
- calcium ion import [IMP]
- carbohydrate phosphorylation [IDA, IMP, ISO]
- cellular glucose homeostasis [IMP, ISO]
- cellular response to glucose starvation [ISO]
- cellular response to insulin stimulus [ISO]
- cellular response to leptin stimulus [ISO]
- detection of glucose [ISO]
- fructose 2,6-bisphosphate metabolic process [ISO]
- glucose 6-phosphate metabolic process [IMP, ISO]
- glucose homeostasis [IMP, ISO]
- glucose metabolic process [IDA, IMP, ISO]
- glycogen biosynthetic process [ISO]
- glycolytic process [IBA, ISO]
- lipid homeostasis [ISO]
- negative regulation of epinephrine secretion [ISO]
- negative regulation of gluconeogenesis [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of glycogen biosynthetic process [ISO]
- positive regulation of glycolytic process [ISO]
- positive regulation of insulin secretion [IMP, ISO]
- positive regulation of phosphorylation [ISO]
- regulation of insulin secretion [IMP, ISO]
- regulation of potassium ion transport [IMP]
- second-messenger-mediated signaling [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin filament [ISO]
- basal cortex [ISO]
- cell [IMP]
- cell cortex [ISO]
- cytoplasm [ISO]
- cytosol [IBA, IDA, ISO]
- mitochondrion [IDA, ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- secretory granule [ISO]
PRKACA
Gene Ontology Biological Process
- cellular response to glucose stimulus [ISO]
- cellular response to parathyroid hormone stimulus [IMP]
- mesoderm formation [IGI]
- negative regulation of meiotic cell cycle [ISO]
- negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [IGI]
- neural tube closure [IGI]
- peptidyl-serine phosphorylation [IDA, ISO]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of protein export from nucleus [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA, ISO]
- regulation of cellular respiration [ISO]
- regulation of osteoblast differentiation [ISO]
- regulation of proteasomal protein catabolic process [ISO]
- regulation of protein processing [IGI]
- regulation of synaptic transmission [IMP]
- regulation of synaptic transmission, glutamatergic [ISO]
- regulation of tight junction assembly [ISO]
- sperm capacitation [IDA]
Gene Ontology Molecular Function- Rab GTPase binding [ISO]
- cAMP-dependent protein kinase activity [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA]
- protein serine/threonine/tyrosine kinase activity [ISO]
- ubiquitin protein ligase binding [ISO]
- Rab GTPase binding [ISO]
- cAMP-dependent protein kinase activity [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA]
- protein serine/threonine/tyrosine kinase activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- AMP-activated protein kinase complex [ISO]
- Golgi apparatus [ISO]
- cAMP-dependent protein kinase complex [ISO]
- centrosome [ISO]
- ciliary base [IDA]
- cytoplasm [IDA, ISO]
- extracellular vesicular exosome [ISO]
- membrane [ISO]
- mitochondrion [IDA]
- neuromuscular junction [IDA]
- neuron projection [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA]
- protein complex [ISO]
- sperm midpiece [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.
Glycolysis and apoptosis are considered major but independent pathways that are critical for cell survival. The activity of BAD, a pro-apoptotic BCL-2 family member, is regulated by phosphorylation in response to growth/survival factors. Here we undertook a proteomic analysis to assess whether BAD might also participate in mitochondrial physiology. In liver mitochondria, BAD resides in a functional holoenzyme complex together ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID