BAD
Gene Ontology Biological Process
- ADP metabolic process [IMP]
- ATP metabolic process [IMP]
- activation of cysteine-type endopeptidase activity [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISO]
- apoptotic process [ISO]
- apoptotic signaling pathway [IDA, IMP]
- cell proliferation [IDA]
- cellular process regulating host cell cycle in response to virus [IDA]
- cellular response to nicotine [ISO]
- cellular response to organic substance [ISO]
- cytokine-mediated signaling pathway [IDA]
- extrinsic apoptotic signaling pathway [ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IDA, IGI, IMP]
- extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- glucose catabolic process [IMP]
- glucose homeostasis [IMP]
- intrinsic apoptotic signaling pathway [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA, IMP]
- pore complex assembly [ISO]
- positive regulation of B cell differentiation [IMP]
- positive regulation of T cell differentiation [IMP]
- positive regulation of apoptotic process [IDA, ISO]
- positive regulation of apoptotic process by virus [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of glucokinase activity [IMP]
- positive regulation of insulin secretion [IMP]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- positive regulation of mitochondrial membrane potential [IMP]
- positive regulation of neuron death [ISO]
- positive regulation of proteolysis [ISO]
- positive regulation of release of cytochrome c from mitochondria [ISO]
- positive regulation of type B pancreatic cell development [IMP]
- regulation of apoptotic process [IDA]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- regulation of mitochondrial membrane permeability [ISO]
- release of cytochrome c from mitochondria [IMP]
- suppression by virus of host apoptotic process [IDA, IMP]
- type B pancreatic cell proliferation [IMP]
Gene Ontology Molecular Function- cysteine-type endopeptidase activator activity involved in apoptotic process [IDA, ISO]
- lipid binding [ISO]
- phospholipid binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2B binding [ISO]
- protein phosphatase binding [IPI]
- cysteine-type endopeptidase activator activity involved in apoptotic process [IDA, ISO]
- lipid binding [ISO]
- phospholipid binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2B binding [ISO]
- protein phosphatase binding [IPI]
Gene Ontology Cellular Component
WASF1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.
Glycolysis and apoptosis are considered major but independent pathways that are critical for cell survival. The activity of BAD, a pro-apoptotic BCL-2 family member, is regulated by phosphorylation in response to growth/survival factors. Here we undertook a proteomic analysis to assess whether BAD might also participate in mitochondrial physiology. In liver mitochondria, BAD resides in a functional holoenzyme complex together ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID