PRKCZ
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- activation of phospholipase D activity [ISO]
- activation of protein kinase B activity [ISO]
- cell migration [ISO]
- cell surface receptor signaling pathway [ISO]
- cellular protein localization [ISO]
- cellular response to insulin stimulus [ISO]
- establishment of cell polarity [ISO]
- insulin receptor signaling pathway [ISO]
- intracellular signal transduction [ISO]
- long-term memory [ISO]
- long-term synaptic potentiation [ISO]
- membrane depolarization [ISO]
- membrane hyperpolarization [ISO]
- microtubule cytoskeleton organization [IGI, IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of hydrolase activity [ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- negative regulation of protein complex assembly [ISO]
- neuron projection extension [IGI]
- peptidyl-serine phosphorylation [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of T-helper 2 cell cytokine production [IMP]
- positive regulation of T-helper 2 cell differentiation [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of excitatory postsynaptic membrane potential [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of insulin receptor signaling pathway [ISO]
- positive regulation of interleukin-10 secretion [IMP]
- positive regulation of interleukin-13 secretion [IMP]
- positive regulation of interleukin-4 production [IMP]
- positive regulation of interleukin-5 secretion [IMP]
- positive regulation of protein transport [ISO]
- positive regulation of synaptic transmission [ISO]
- protein heterooligomerization [ISO]
- protein kinase C signaling [ISO]
- protein localization to plasma membrane [IMP]
- protein phosphorylation [IDA, ISO]
- signal transduction [ISO]
- vesicle transport along microtubule [ISO]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- ATP binding [ISO]
- phospholipase binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase C activity [ISO]
- protein kinase activity [IDA, ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- 14-3-3 protein binding [ISO]
- ATP binding [ISO]
- phospholipase binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase C activity [ISO]
- protein kinase activity [IDA, ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
Gene Ontology Cellular Component
- apical cortex [IDA]
- apical plasma membrane [IDA]
- axon hillock [IDA]
- cell cortex [IDA]
- cell leading edge [ISO]
- cell-cell junction [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- filamentous actin [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane raft [ISO]
- microtubule organizing center [IGI]
- myelin sheath abaxonal region [IDA]
- nuclear envelope [IDA]
- nuclear matrix [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- protein complex [IDA, ISO]
- tight junction [IDA]
PKM
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Identification of PKCzetaII: an endogenous inhibitor of cell polarity.
A new member of the atypical protein kinase C (aPKC) family, designated PKCzetaII, is identified in this study. The gene contains no introns and is 98% homologous with the cDNA encoding PKCzeta. The PKCzetaII coding region is frame-shifted with respect to the PKCzeta open reading frame, resulting in expression of an aPKC regulatory domain without associated kinase activity. PKCzetaII mRNA ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID