RGF3
Gene Ontology Biological Process
- actin cortical patch localization [IMP]
- positive regulation of Rho GTPase activity [IGI]
- primary cell septum disassembly [IMP]
- regulation of Rho protein signal transduction [IGI]
- regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process [IC]
- regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [IMP]
- regulation of mitotic cytokinetic cell separation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RGF1
Gene Ontology Biological Process
- actin cortical patch localization [IMP]
- fungal-type cell wall biogenesis [IGI]
- positive regulation of Rho GTPase activity [IGI]
- positive regulation of Rho protein signal transduction [IGI]
- positive regulation of bipolar cell growth [IMP]
- regulation of Rho GTPase activity [IGI]
- regulation of cell shape [IGI]
- regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
Rho1-GEFs Rgf1 and Rgf2 are involved in formation of cell wall and septum, while Rgf3 is involved in cytokinesis in fission yeast.
The Rho GTPase acts as a binary molecular switch by converting between a GDP-bound inactive and a GTP-bound active conformational state. The guanine nucleotide exchange factors (GEFs) are critical activators of Rho. Rho1 has been shown to regulate actin cytoskeleton and cell wall synthesis in the fission yeast Schizosaccharomyces pombe. Here we studied function of fission yeast RhoGEFs, Rgf1, Rgf2, ... [more]
Throughput
- Low Throughput
Ontology Terms
- vegetative growth (APO:0000106)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RGF1 RGF3 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 795710 | |
| RGF3 RGF1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 452597 |
Curated By
- BioGRID