BAIT
PHB2
AU044498, BAP, Bap37, Bcap37, REA
prohibitin 2
GO Process (6)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
- mammary gland alveolus development [IMP]
- mammary gland branching involved in thelarche [IMP]
- negative regulation of intracellular estrogen receptor signaling pathway [IGI, IMP]
- negative regulation of mammary gland epithelial cell proliferation [IMP]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- regulation of branching involved in mammary gland duct morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MEF2C
5430401D19Rik, 9930028G15Rik, AV011172, Mef2
myocyte enhancer factor 2C
GO Process (82)
GO Function (22)
GO Component (9)
Gene Ontology Biological Process
- B cell homeostasis [IMP]
- B cell proliferation [IMP]
- B cell receptor signaling pathway [IMP]
- MAPK cascade [IDA, IMP, ISO]
- blood vessel development [IMP]
- blood vessel remodeling [IMP]
- cardiac muscle cell differentiation [IGI, NAS]
- cardiac muscle hypertrophy in response to stress [IMP]
- cardiac ventricle formation [IGI, IMP]
- cartilage morphogenesis [IMP]
- cell fate commitment [IMP]
- cellular response to calcium ion [IDA]
- cellular response to drug [IDA]
- cellular response to fluid shear stress [IDA]
- cellular response to growth factor stimulus [ISO]
- cellular response to lipopolysaccharide [IDA]
- cellular response to parathyroid hormone stimulus [ISO]
- cellular response to retinoic acid [ISO]
- cellular response to transforming growth factor beta stimulus [ISO]
- cellular response to trichostatin A [IDA]
- chondrocyte differentiation [IGI]
- embryonic skeletal system morphogenesis [IMP]
- embryonic viscerocranium morphogenesis [IMP]
- endochondral ossification [IGI, IMP]
- epithelial cell proliferation involved in renal tubule morphogenesis [IMP]
- germinal center formation [IMP]
- glomerulus morphogenesis [IMP]
- heart development [IMP]
- heart looping [IMP]
- humoral immune response [IMP]
- learning or memory [IMP]
- melanocyte differentiation [IMP]
- monocyte differentiation [IMP]
- muscle cell fate determination [IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of gene expression [IMP]
- negative regulation of neuron apoptotic process [IDA, ISO]
- negative regulation of ossification [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- nephron tubule epithelial cell differentiation [IMP]
- neural crest cell differentiation [IMP]
- neuron development [IMP]
- neuron differentiation [IMP]
- osteoblast differentiation [IGI]
- outflow tract morphogenesis [IGI]
- palate development [IGI]
- platelet formation [IMP]
- positive regulation of B cell proliferation [IMP]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of alkaline phosphatase activity [IMP]
- positive regulation of behavioral fear response [IMP]
- positive regulation of bone mineralization [IMP]
- positive regulation of cardiac muscle cell differentiation [IMP, ISO]
- positive regulation of cardiac muscle cell proliferation [IMP]
- positive regulation of cardiac muscle hypertrophy [ISO]
- positive regulation of cell proliferation in bone marrow [IGI]
- positive regulation of gene expression [IDA, IMP, ISO]
- positive regulation of macrophage apoptotic process [IMP]
- positive regulation of myoblast differentiation [ISO]
- positive regulation of neuron differentiation [IDA]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of protein homodimerization activity [IDA]
- positive regulation of skeletal muscle cell differentiation [ISO]
- positive regulation of skeletal muscle tissue development [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO]
- primary heart field specification [IMP]
- regulation of germinal center formation [IMP]
- regulation of megakaryocyte differentiation [IMP]
- regulation of sarcomere organization [IMP]
- regulation of synaptic activity [IMP]
- regulation of transcription, DNA-templated [IDA, ISO]
- renal tubule morphogenesis [IMP]
- response to ischemia [ISO]
- secondary heart field specification [IMP]
- sinoatrial valve morphogenesis [IMP]
- skeletal muscle cell differentiation [IMP, NAS]
- skeletal muscle tissue development [IMP]
- smooth muscle cell differentiation [IMP]
- transcription from RNA polymerase II promoter [IMP, ISO]
- transdifferentiation [ISO]
- ventricular cardiac muscle cell differentiation [IMP]
Gene Ontology Molecular Function- AT DNA binding [ISO]
- DNA binding [IDA, ISO]
- HMG box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP, ISO]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA, ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA]
- core promoter proximal region sequence-specific DNA binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- histone deacetylase binding [IPI]
- miRNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription regulatory region DNA binding [IDA]
- AT DNA binding [ISO]
- DNA binding [IDA, ISO]
- HMG box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP, ISO]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA, ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA]
- core promoter proximal region sequence-specific DNA binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- histone deacetylase binding [IPI]
- miRNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation.
In a yeast two-hybrid screen using the full-length Akt as bait, we found that prohibitin 2 (PHB2) specifically interacts with Akt. The C terminus of Akt (amino acids 413-480) and a central region of PHB2 (amino acids 120-232) are responsible for their mutual interaction. PHB2 acts as a transcriptional repressor in cells. PHB2 interacts with both MyoD and MEF2, and ... [more]
J. Cell. Sci. Jun. 15, 2004; 117(0);3021-9 [Pubmed: 15173318]
Throughput
- Low Throughput
Curated By
- BioGRID