BAIT
AGTR1A
1810074K20Rik, AG2S, AI551199, AT1, AT1a, AT2R1, AT2R1A, Agtr-1a, Agtr1, Angtr-1a
angiotensin II receptor, type 1a
GO Process (38)
GO Function (10)
GO Component (15)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IC, ISO]
- Rho protein signal transduction [ISO]
- activation of Janus kinase activity [ISO]
- angiotensin-activated signaling pathway [ISO]
- blood vessel development [IGI]
- brain renin-angiotensin system [IMP]
- calcium-mediated signaling [ISO]
- cell chemotaxis [ISO]
- cellular response to dexamethasone stimulus [ISO]
- dopamine biosynthetic process [ISO]
- drinking behavior [IGI, IMP, ISO]
- heart development [IMP]
- inflammatory response [IGI]
- kidney development [IGI, IMP, ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of smooth muscle cell apoptotic process [IMP]
- phospholipase C-activating G-protein coupled receptor signaling pathway [ISO]
- phospholipase C-activating angiotensin-activated signaling pathway [IDA, ISO]
- positive regulation of blood pressure [IDA, IGI, IMP, ISO]
- positive regulation of branching involved in ureteric bud morphogenesis [ISO]
- positive regulation of cell proliferation [IMP, ISO]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of cholesterol esterification [ISO]
- positive regulation of cytokine secretion [IMP]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO]
- positive regulation of phospholipase A2 activity [ISO]
- positive regulation of receptor recycling [ISO]
- positive regulation of superoxide anion generation [ISO]
- regulation of pH [ISO]
- regulation of renal output by angiotensin [IMP]
- regulation of smooth muscle cell apoptotic process [IGI]
- regulation of systemic arterial blood pressure by circulatory renin-angiotensin [IGI]
- regulation of vasoconstriction [ISO]
- renin secretion into blood stream [IMP]
- renin-angiotensin regulation of aldosterone production [IMP, ISO]
- response to estrogen [ISO]
- vasoconstriction [ISO]
Gene Ontology Molecular Function- D1 dopamine receptor binding [ISO]
- G-protein alpha-subunit binding [ISO]
- angiotensin type I receptor activity [IDA, ISO]
- angiotensin type II receptor activity [ISO]
- bradykinin receptor binding [ISO]
- peptide hormone binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- protein self-association [ISO]
- D1 dopamine receptor binding [ISO]
- G-protein alpha-subunit binding [ISO]
- angiotensin type I receptor activity [IDA, ISO]
- angiotensin type II receptor activity [ISO]
- bradykinin receptor binding [ISO]
- peptide hormone binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- protein self-association [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- basolateral plasma membrane [ISO]
- cell [IMP]
- cytoplasm [IDA]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- dendrite [ISO]
- endomembrane system [ISO]
- endosome [IDA]
- membrane [ISO]
- organelle outer membrane [ISO]
- plasma membrane [IDA, ISO]
- recycling endosome [ISO]
- vesicle lumen [ISO]
- vesicle membrane [ISO]
Mus musculus
PREY
ARRB1
1200006I17Rik, AW208571, G430100A01Rik
arrestin, beta 1
GO Process (34)
GO Function (19)
GO Component (12)
Gene Ontology Biological Process
- G-protein coupled receptor internalization [ISO]
- G-protein coupled receptor signaling pathway [ISO]
- activation of MAPK activity [ISO]
- endocytosis [ISO]
- follicle-stimulating hormone signaling pathway [ISO]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of GTPase activity [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of interleukin-6 production [ISO]
- negative regulation of interleukin-8 production [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of protein ubiquitination [ISO]
- phototransduction [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of Rho protein signal transduction [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of histone H4 acetylation [ISO]
- positive regulation of histone acetylation [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of protein binding [IMP]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of receptor internalization [ISO]
- positive regulation of smooth muscle cell apoptotic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein ubiquitination [ISO]
- receptor-mediated endocytosis [ISO]
- regulation of G-protein coupled receptor protein signaling pathway [IMP, ISO]
- stress fiber assembly [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- AP-2 adaptor complex binding [ISO]
- GTPase activator activity [ISO]
- V2 vasopressin receptor binding [ISO]
- alpha-1A adrenergic receptor binding [ISO]
- alpha-1B adrenergic receptor binding [ISO]
- angiotensin receptor binding [ISO]
- clathrin adaptor activity [ISO]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IMP]
- estrogen receptor binding [ISO]
- follicle-stimulating hormone receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- ion channel binding [ISO]
- mitogen-activated protein kinase kinase binding [IDA]
- phosphoprotein binding [ISO]
- protein binding [IPI]
- protein phosphorylated amino acid binding [ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
- AP-2 adaptor complex binding [ISO]
- GTPase activator activity [ISO]
- V2 vasopressin receptor binding [ISO]
- alpha-1A adrenergic receptor binding [ISO]
- alpha-1B adrenergic receptor binding [ISO]
- angiotensin receptor binding [ISO]
- clathrin adaptor activity [ISO]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IMP]
- estrogen receptor binding [ISO]
- follicle-stimulating hormone receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- ion channel binding [ISO]
- mitogen-activated protein kinase kinase binding [IDA]
- phosphoprotein binding [ISO]
- protein binding [IPI]
- protein phosphorylated amino acid binding [ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Association of beta-Arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus and correlates with receptor internalization.
Arrestins bind to phosphorylated G protein-coupled receptors and participate in receptor desensitization and endocytosis. Although arrestins traffic with activated type 1 (AT(1A)) angiotensin II (AngII) receptors, the contribution of arrestins to AT(1A) receptor internalization is controversial, and the physical association of arrestins with the AT(1A) receptor has not been established. In this study, by coimmunoprecipitating AT(1A) receptors and beta-arrestin 1, ... [more]
Mol. Endocrinol. Oct. 01, 2001; 15(10);1706-19 [Pubmed: 11579203]
Throughput
- Low Throughput
Additional Notes
- source of proteins unclear
Curated By
- BioGRID