RHEB
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BNIP3
Gene Ontology Biological Process
- apoptotic process [ISO]
- autophagic cell death [ISO]
- brown fat cell differentiation [IDA]
- cell death [ISO]
- cellular response to cobalt ion [ISO]
- cellular response to hydrogen peroxide [ISO]
- cellular response to hypoxia [ISO]
- defense response to virus [ISO]
- granzyme-mediated apoptotic signaling pathway [ISO]
- intrinsic apoptotic signaling pathway [IGI, IMP]
- intrinsic apoptotic signaling pathway in response to hypoxia [ISO]
- mitochondrial fragmentation involved in apoptotic process [ISO]
- mitochondrial outer membrane permeabilization [IBA, ISO]
- mitochondrial protein catabolic process [ISO]
- negative regulation of membrane potential [ISO]
- negative regulation of mitochondrial fusion [ISO]
- neuron apoptotic process [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of mitochondrial fission [ISO]
- positive regulation of programmed cell death [IBA, ISO]
- positive regulation of protein complex disassembly [ISO]
- positive regulation of release of cytochrome c from mitochondria [ISO]
- reactive oxygen species metabolic process [ISO]
- regulation of mitochondrial membrane permeability [ISO]
- response to hypoxia [ISO]
- toxin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [ISO]
- dendrite [ISO]
- endoplasmic reticulum [IBA]
- integral component of mitochondrial outer membrane [ISO]
- intracellular [IGI]
- mitochondrial membrane [IDA, ISO]
- mitochondrial outer membrane [IBA, ISO]
- mitochondrion [IDA, ISO]
- neuronal postsynaptic density [IDA]
- nuclear envelope [IBA, ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb.
The mammalian target of rapamycin (mTOR) is a central controller of cell growth, and it regulates translation, cell size, cell viability, and cell morphology. mTOR integrates a wide range of extracellular and intracellular signals, including growth factors, nutrients, energy levels, and stress conditions. Rheb, a Ras-related small GTPase, is a key upstream activator of mTOR. In this study, we found ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID