AURKB
Gene Ontology Biological Process
- abscission [ISS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- attachment of spindle microtubules to kinetochore [TAS]
- cellular response to UV [IDA]
- cleavage furrow formation [IDA]
- cytokinesis checkpoint [ISS]
- histone H3-S28 phosphorylation [ISS]
- histone modification [TAS]
- mitotic cell cycle [TAS]
- mitotic spindle midzone assembly [IMP, TAS]
- negative regulation of B cell apoptotic process [IDA]
- negative regulation of cytokinesis [ISS]
- negative regulation of protein binding [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of cytokinesis [IMP, TAS]
- protein autophosphorylation [TAS]
- protein localization to kinetochore [IMP]
- protein phosphorylation [IDA]
- regulation of chromosome segregation [TAS]
- spindle stabilization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PPP2CA
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- RNA splicing [NAS]
- apoptotic process [TAS]
- ceramide metabolic process [NAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- inactivation of MAPK activity [NAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- mitotic nuclear envelope reassembly [TAS]
- negative regulation of cell growth [NAS]
- negative regulation of epithelial to mesenchymal transition [IMP]
- negative regulation of tyrosine phosphorylation of Stat3 protein [NAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- positive regulation of protein serine/threonine kinase activity [IMP]
- protein dephosphorylation [TAS]
- regulation of DNA replication [NAS]
- regulation of Wnt signaling pathway [NAS]
- regulation of cell adhesion [NAS]
- regulation of cell differentiation [NAS]
- regulation of growth [NAS]
- regulation of transcription, DNA-templated [NAS]
- response to organic substance [NAS]
- second-messenger-mediated signaling [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
EB1 promotes Aurora-B kinase activity through blocking its inactivation by protein phosphatase 2A.
EB1 (end-binding protein 1) is a key player in the regulation of microtubule dynamics. In concert with its binding partners, adenomatous polyposis coli and p150(glued), EB1 plays a crucial role in a variety of microtubule-based cellular processes. In this study we have identified in a yeast two-hybrid screen the mitotic kinase and chromosome passenger protein Aurora-B as a binding partner ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID