BAIT

RHO3

Rho family GTPase RHO3, L000001632, YIL118W
Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
GO Process (3)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

RHO4

Rho family GTPase RHO4, L000001633, YKR055W
Non-essential small GTPase; member of the Rho/Rac subfamily of Ras-like proteins; likely to be involved in the establishment of cell polarity; has long N-terminal extension that plays an important role in Rho4p function and is shared with Rho4 homologs in other yeasts and filamentous fungi
GO Process (3)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Control of Polarized Growth by the Rho-family GTPase Rho4 in the Budding Yeast: Requirement of the N-Terminal Extension of Rho4 and the Regulation by the RhoGAP Bem2.

Gong T, Liao Y, He F, Yang Y, Yang DD, Chen XD, Gao XD

In the budding yeast Saccharomyces cerevisiae, Rho4 GTPase partially plays a redundant role with Rho3 in the control of polarized growth as deletion of RHO4 and RHO3 together, but not RHO4 alone, caused lethality and a loss of cell polarity at 30°C. Here, we show that overexpression of constitutively active rho4(Q131L) mutant in an rdi1Δ strain caused a severe growth ... [more]

Eukaryotic Cell Dec. 21, 2012; 0(0); [Pubmed: 23264647]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: budding (APO:0000024)

Additional Notes

  • rho4delta61 allele, which removes the N-terminal 61 residues

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
RHO3 RHO4
Dosage Rescue
Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Low-BioGRID
155203
RHO3 RHO4
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
158662
RHO3 RHO4
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
644664
RHO3 RHO4
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
158664
RHO3 RHO4
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
657069

Curated By

  • BioGRID