CDC42
Gene Ontology Biological Process
- budding cell apical bud growth [IMP]
- budding cell isotropic bud growth [IMP]
- conjugation with cellular fusion [IMP]
- establishment of cell polarity [IMP]
- invasive growth in response to glucose limitation [IMP]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IGI, IMP]
- positive regulation of exocytosis [IGI, IMP, IPI]
- positive regulation of pseudohyphal growth [IMP]
- regulation of exit from mitosis [IMP]
- regulation of exocyst localization [IMP]
- regulation of initiation of mating projection growth [IMP]
- regulation of vacuole fusion, non-autophagic [IMP]
- septin ring organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BEM2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Control of Polarized Growth by the Rho-family GTPase Rho4 in the Budding Yeast: Requirement of the N-Terminal Extension of Rho4 and the Regulation by the RhoGAP Bem2.
In the budding yeast Saccharomyces cerevisiae, Rho4 GTPase partially plays a redundant role with Rho3 in the control of polarized growth as deletion of RHO4 and RHO3 together, but not RHO4 alone, caused lethality and a loss of cell polarity at 30°C. Here, we show that overexpression of constitutively active rho4(Q131L) mutant in an rdi1Δ strain caused a severe growth ... [more]
Throughput
- Low Throughput
Additional Notes
- interaction observed with Cdc42-G12V allele
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BEM2 CDC42 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 139945 | |
| CDC42 BEM2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1462 | BioGRID | 2001244 | |
| CDC42 BEM2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 1870037 |
Curated By
- BioGRID