IKBKG
Gene Ontology Biological Process
- B cell homeostasis [IMP]
- activation of NF-kappaB-inducing kinase activity [IDA]
- cellular response to DNA damage stimulus [ISO]
- establishment of vesicle localization [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IBA, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- K63-linked polyubiquitin binding [IDA]
- linear polyubiquitin binding [ISO]
- peroxisome proliferator activated receptor binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- ubiquitin protein ligase binding [ISO]
- K63-linked polyubiquitin binding [IDA]
- linear polyubiquitin binding [ISO]
- peroxisome proliferator activated receptor binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
CHUK
Gene Ontology Biological Process
- I-kappaB phosphorylation [ISO, TAS]
- Rho protein signal transduction [ISO]
- cellular response to tumor necrosis factor [ISO]
- lactation [IGI, IMP]
- mammary gland alveolus development [IGI, IMP]
- mammary gland epithelial cell proliferation [IGI, IMP]
- morphogenesis of an epithelial sheet [IMP]
- odontogenesis of dentin-containing tooth [IMP]
- osteoclast differentiation [IGI, IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein phosphorylation [IDA, ISO]
- response to lipopolysaccharide [ISO]
- response to muscle stretch [IMP]
- response to organic substance [ISO]
- signal transduction by phosphorylation [TAS]
- striated muscle cell differentiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction.
Signaling through its widely distributed cell surface receptor, interleukin (IL)-17 enhances the transcription of genes encoding proinflammatory molecules. Although it has been well documented that IL-17 activates the transcription factor nuclear factor (NF)-kappaB and c-Jun NH(2)-terminal kinase (JNK), the upstream signaling events are largely unknown. Here we report the requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in IL-17-induced NF-kappaB ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IKBKG CHUK | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| IKBKG CHUK | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 882993 | |
| IKBKG CHUK | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CHUK IKBKG | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| IKBKG CHUK | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID