HOMER1
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [ISO, TAS]
- behavioral response to cocaine [IMP]
- chemical homeostasis within a tissue [IMP]
- positive regulation of calcium ion transport [IMP]
- protein localization to synapse [ISO]
- regulation of calcium ion import [IMP]
- regulation of cation channel activity [IMP]
- regulation of store-operated calcium entry [IMP]
- response to calcium ion [ISO]
- skeletal muscle contraction [IMP]
- skeletal muscle fiber development [IMP]
Gene Ontology Molecular Function- G-protein coupled glutamate receptor binding [IBA, ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- protein binding [IPI]
- protein complex scaffold [ISO]
- protein heterodimerization activity [ISO]
- receptor binding [ISO]
- scaffold protein binding [ISO]
- type 5 metabotropic glutamate receptor binding [ISO]
- G-protein coupled glutamate receptor binding [IBA, ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- protein binding [IPI]
- protein complex scaffold [ISO]
- protein heterodimerization activity [ISO]
- receptor binding [ISO]
- scaffold protein binding [ISO]
- type 5 metabotropic glutamate receptor binding [ISO]
Gene Ontology Cellular Component
GRM1
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [IBA, ISO]
- G-protein coupled receptor signaling pathway [ISO]
- activation of MAPK activity [IDA]
- activation of MAPKK activity [IDA]
- calcium-mediated signaling [ISO]
- cellular response to electrical stimulus [IMP]
- dimeric G-protein coupled receptor signaling pathway [ISO]
- locomotory behavior [IMP]
- phospholipase C-activating G-protein coupled glutamate receptor signaling pathway [TAS]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IBA]
- regulation of MAPK cascade [IDA]
- regulation of sensory perception of pain [IDA]
- regulation of synaptic transmission, glutamatergic [IBA, ISO]
- sensory perception of pain [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- G-protein coupled receptor dimeric complex [ISO]
- G-protein coupled receptor homodimeric complex [ISO]
- axon [ISO]
- cytosol [ISO]
- dendrite [IDA]
- dendritic spine [ISO]
- integral component of plasma membrane [IBA, ISO]
- intracellular [ISO]
- neuron projection [IDA]
- neuronal cell body [TAS]
- nucleus [IDA]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [TAS]
- presynaptic membrane [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain.
Upon activation of cell surface receptors coupled to the Gq subclass of G proteins, phospholipase C (PLC) beta hydrolyses membrane phospholipid to yield a pair of second messengers, inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol. PLCbeta4 has been characterized as the isoform enriched in cerebellar Purkinje cells (PCs) and the retina and involved in motor and visual functions. Here we examined cellular ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
HOMER1 GRM1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2340097 |
Curated By
- BioGRID