BAIT
CASP6
Mch2, mCASP-6
caspase 6
GO Process (10)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- acute inflammatory response to non-antigenic stimulus [ISO]
- apoptotic process [IBA]
- positive regulation of apoptotic process [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of retinal cell programmed cell death [ISO]
- proteolysis [IBA, ISO]
- response to cytokine [ISO]
- response to glucose [ISO]
- response to hydrogen peroxide [ISO]
- response to iron ion [ISO]
Gene Ontology Molecular Function
Mus musculus
PREY
CRYAB
Crya-2, Crya2, HspB5, P23
crystallin, alpha B
GO Process (19)
GO Function (7)
GO Component (14)
Gene Ontology Biological Process
- apoptotic process involved in morphogenesis [IGI]
- camera-type eye development [IGI]
- cellular response to gamma radiation [ISO]
- lens development in camera-type eye [IGI]
- microtubule polymerization or depolymerization [ISO]
- muscle organ development [IGI]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IGI]
- negative regulation of gene expression [IMP]
- negative regulation of intracellular transport [ISO]
- negative regulation of reactive oxygen species metabolic process [ISO]
- protein folding [ISO]
- protein homooligomerization [ISO]
- regulation of cell death [ISO]
- response to hydrogen peroxide [IMP]
- response to hypoxia [IMP]
- stress-activated MAPK cascade [ISO]
- tubulin complex assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
Caspase-dependent secondary lens fiber cell disintegration in alphaA-/alphaB-crystallin double-knockout mice.
alphaB-crystallin has been demonstrated, in tissue culture experiments, to be a caspase 3 inhibitor; however, no animal model studies have yet been described. Here, we show that morphological abnormalities in lens secondary fiber cells of alphaA-/alphaB-crystallin gene double knockout (DKO) mice are consistent with, and probably result from, elevated DEVDase and VEIDase activities, corresponding to caspase 3 and caspase 6, ... [more]
Development Mar. 01, 2006; 133(5);813-21 [Pubmed: 16439475]
Throughput
- Low Throughput
Curated By
- BioGRID