PRKCQ
Gene Ontology Biological Process
- intracellular signal transduction [IMP, ISO]
- membrane protein ectodomain proteolysis [IDA]
- negative regulation of T cell apoptotic process [ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- positive regulation of NF-kappaB import into nucleus [ISO]
- positive regulation of NF-kappaB transcription factor activity [IMP, ISA, ISO]
- positive regulation of T cell activation [IMP]
- positive regulation of T cell proliferation [IMP]
- positive regulation of T-helper 17 type immune response [IMP]
- positive regulation of T-helper 2 cell activation [IMP]
- positive regulation of filopodium assembly [ISO]
- positive regulation of interleukin-17 production [IMP]
- positive regulation of interleukin-2 biosynthetic process [IMP]
- positive regulation of interleukin-4 production [IMP]
- positive regulation of protein secretion [ISO]
- positive regulation of stress fiber assembly [ISO]
- protein phosphorylation [IDA]
- regulation of G2/M transition of mitotic cell cycle [ISO]
- regulation of platelet aggregation [IMP]
- regulation of transcription, DNA-templated [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MAP2K7
Gene Ontology Biological Process
- JNK cascade [ISO]
- activation of JUN kinase activity [IDA, ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- response to UV [ISO]
- response to heat [ISO]
- response to osmotic stress [ISO]
- response to stress [IDA]
- response to tumor necrosis factor [ISO]
- stress-activated MAPK cascade [IDA, ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
ADAP Regulates Cell Cycle Progression of T Cells via Control of Cyclin E and Cdk2 Expression through Two Distinct CARMA1-Dependent Signaling Pathways.
Adhesion and degranulation-promoting adapter protein (ADAP) is a multifunctional scaffold that regulates T cell receptor-mediated activation of integrins via association with the SKAP55 adapter and the NF-κB pathway through interactions with both the CARMA1 adapter and serine/threonine kinase transforming growth factor β-activated kinase 1 (TAK1). ADAP-deficient T cells exhibit impaired proliferation following T cell receptor stimulation, but the contribution of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID