HOOK1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ANK3
Gene Ontology Biological Process
- Golgi to plasma membrane protein transport [ISO]
- axon guidance [IMP]
- axonogenesis [IMP]
- establishment of protein localization [ISO]
- maintenance of protein location in plasma membrane [ISO]
- membrane assembly [ISO]
- mitotic cytokinesis [ISO]
- neuronal action potential [IMP]
- plasma membrane organization [ISO]
- positive regulation of action potential [TAS]
- positive regulation of cation channel activity [ISO]
- positive regulation of cell communication by electrical coupling [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of homotypic cell-cell adhesion [ISO]
- positive regulation of membrane depolarization during cardiac muscle cell action potential [ISO]
- positive regulation of membrane potential [ISO]
- positive regulation of protein targeting to membrane [ISO]
- positive regulation of sodium ion transmembrane transporter activity [ISO]
- positive regulation of sodium ion transport [ISO]
- protein localization to plasma membrane [IDA, IMP, ISO]
- protein targeting to plasma membrane [IMP, ISO]
- regulation of potassium ion transport [ISO]
- synapse organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISO]
- Z disc [ISO]
- axon [IDA]
- axon initial segment [IDA, ISO]
- basal plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- cell [IMP]
- cell surface [ISO]
- dendrite [ISO]
- intercalated disc [IDA, ISO]
- intracellular [IMP]
- lateral plasma membrane [ISO]
- membrane [IDA]
- neuromuscular junction [ISO]
- neuron projection [ISO]
- node of Ranvier [IDA, ISO]
- paranode region of axon [IDA]
- plasma membrane [ISO]
- postsynaptic membrane [ISO]
- sarcolemma [ISO]
- sarcoplasmic reticulum [ISO]
- spectrin-associated cytoskeleton [ISO]
- synapse [IDA]
- tight junction [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Elevation of Hook1 in a disease model of Batten disease does not affect a novel interaction between Ankyrin G and Hook1.
Hook1 is a member of a family of microtubule-binding proteins. Studies on the Drosophila homolog of Hook1 have suggested a role in the maturation and trafficking of internalized proteins to the late endosome. A weak interaction between Hook1 and the lysosomal/late endosomal protein, CLN3, was recently reported. Mutations in CLN3 result in the neurological disorder Batten disease. Here we show ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ANK3 HOOK1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID