RIMS2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAB3A
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Rab protein signal transduction [IBA]
- axonogenesis [IMP]
- intracellular protein transport [IBA]
- lung development [IMP]
- maintenance of presynaptic active zone structure [IMP]
- mitochondrion organization [IMP]
- neuromuscular synaptic transmission [IMP]
- positive regulation of ATPase activity [ISO]
- positive regulation of regulated secretory pathway [ISO]
- post-embryonic development [IMP]
- protein secretion [IBA]
- regulation of exocytosis [IDA]
- regulation of synaptic vesicle fusion to presynaptic membrane [IMP]
- respiratory system process [IMP]
- response to electrical stimulus [IMP]
- sensory perception of touch [IMP]
- synaptic vesicle exocytosis [IMP, ISO]
- synaptic vesicle maturation [IMP]
- synaptic vesicle recycling [ISO]
- vesicle docking involved in exocytosis [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
cAMP-GEFII is a direct target of cAMP in regulated exocytosis.
Although cAMP is well known to regulate exocytosis in many secretory cells, its direct target in the exocytotic machinery is not known. Here we show that cAMP-GEFII, a cAMP sensor, binds to Rim (Rab3-interacting molecule, Rab3 being a small G protein) and to a new isoform, Rim2, both of which are putative regulators of fusion of vesicles to the plasma ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RIMS2 RAB3A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1415016 |
Curated By
- BioGRID