RIMS1
Gene Ontology Biological Process
- calcium ion-dependent exocytosis of neurotransmitter [IGI]
- long-term synaptic potentiation [ISO]
- positive regulation of inhibitory postsynaptic membrane potential [ISO]
- positive regulation of synaptic vesicle priming [ISO]
- protein complex assembly [ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of membrane potential [IDA]
- regulation of synaptic vesicle exocytosis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAPGEF4
Gene Ontology Biological Process
- cAMP-mediated signaling [IDA]
- calcium ion-dependent exocytosis [IDA]
- insulin secretion [IDA]
- negative regulation of synaptic transmission [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of Ras GTPase activity [IDA]
- positive regulation of smooth muscle cell migration [ISO]
- regulation of dendrite development [ISO]
- regulation of exocytosis [IDA]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
cAMP-GEFII is a direct target of cAMP in regulated exocytosis.
Although cAMP is well known to regulate exocytosis in many secretory cells, its direct target in the exocytotic machinery is not known. Here we show that cAMP-GEFII, a cAMP sensor, binds to Rim (Rab3-interacting molecule, Rab3 being a small G protein) and to a new isoform, Rim2, both of which are putative regulators of fusion of vesicles to the plasma ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID