PRKCD
Gene Ontology Biological Process
- B cell proliferation [IMP]
- apoptotic process [ISO]
- aspartate transport [ISO]
- cellular senescence [ISO]
- collagen metabolic process [ISO]
- defense response to bacterium [IMP]
- immunoglobulin mediated immune response [IMP]
- interleukin-10 production [IMP]
- interleukin-12 production [IMP]
- intracellular signal transduction [ISO]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of actin filament polymerization [IMP]
- negative regulation of filopodium assembly [IMP]
- negative regulation of glial cell apoptotic process [ISO]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of peptidyl-tyrosine phosphorylation [IMP]
- negative regulation of platelet aggregation [IMP]
- neutrophil activation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of apoptotic signaling pathway [IDA]
- positive regulation of ceramide biosynthetic process [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glucosylceramide catabolic process [ISO]
- positive regulation of phospholipid scramblase activity [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of response to DNA damage stimulus [ISO]
- positive regulation of sphingomyelin catabolic process [ISO]
- positive regulation of superoxide anion generation [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- response to oxidative stress [ISO]
- termination of signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GAP43
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Phosphorylation of GAP-43 (growth-associated protein of 43 kDa) by conventional, novel and atypical isotypes of the protein kinase C gene family: differences between oligopeptide and polypeptide phosphorylation.
GAP-43 (growth-associated protein of 43 kDa; also known as neuromodulin, P-57, B-50 and F-1) is a neuronal calmodulin binding protein and a major protein kinase C (PKC) substrate in mammalian brain. Here we describe the phosphorylation by and the site specificity of different PKC isotypes. The conventional PKC beta 1 and the novel PKCs delta and epsilon effectively phosphorylated recombinant ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID