BAIT
PRKCZ
AI098070, C80388, Pkcz, R74924, aPKCzeta, nPKC-zeta, zetaPKC, RP23-298E4.6
protein kinase C, zeta
GO Process (43)
GO Function (10)
GO Component (21)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- activation of phospholipase D activity [ISO]
- activation of protein kinase B activity [ISO]
- cell migration [ISO]
- cell surface receptor signaling pathway [ISO]
- cellular protein localization [ISO]
- cellular response to insulin stimulus [ISO]
- establishment of cell polarity [ISO]
- insulin receptor signaling pathway [ISO]
- intracellular signal transduction [ISO]
- long-term memory [ISO]
- long-term synaptic potentiation [ISO]
- membrane depolarization [ISO]
- membrane hyperpolarization [ISO]
- microtubule cytoskeleton organization [IGI, IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of hydrolase activity [ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- negative regulation of protein complex assembly [ISO]
- neuron projection extension [IGI]
- peptidyl-serine phosphorylation [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of T-helper 2 cell cytokine production [IMP]
- positive regulation of T-helper 2 cell differentiation [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of excitatory postsynaptic membrane potential [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of insulin receptor signaling pathway [ISO]
- positive regulation of interleukin-10 secretion [IMP]
- positive regulation of interleukin-13 secretion [IMP]
- positive regulation of interleukin-4 production [IMP]
- positive regulation of interleukin-5 secretion [IMP]
- positive regulation of protein transport [ISO]
- positive regulation of synaptic transmission [ISO]
- protein heterooligomerization [ISO]
- protein kinase C signaling [ISO]
- protein localization to plasma membrane [IMP]
- protein phosphorylation [IDA, ISO]
- signal transduction [ISO]
- vesicle transport along microtubule [ISO]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- ATP binding [ISO]
- phospholipase binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase C activity [ISO]
- protein kinase activity [IDA, ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- 14-3-3 protein binding [ISO]
- ATP binding [ISO]
- phospholipase binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase C activity [ISO]
- protein kinase activity [IDA, ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
Gene Ontology Cellular Component
- apical cortex [IDA]
- apical plasma membrane [IDA]
- axon hillock [IDA]
- cell cortex [IDA]
- cell leading edge [ISO]
- cell-cell junction [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- filamentous actin [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane raft [ISO]
- microtubule organizing center [IGI]
- myelin sheath abaxonal region [IDA]
- nuclear envelope [IDA]
- nuclear matrix [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- protein complex [IDA, ISO]
- tight junction [IDA]
Mus musculus
PREY
PRKCZ
14-3-3-zetaisoform, Pkcz, r14-3-3
protein kinase C, zeta
GO Process (43)
GO Function (10)
GO Component (21)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [IMP]
- activation of phospholipase D activity [IMP]
- activation of protein kinase B activity [IMP]
- cell migration [IMP]
- cell surface receptor signaling pathway [IMP]
- cellular protein localization [IMP]
- cellular response to insulin stimulus [IMP]
- establishment of cell polarity [IMP]
- insulin receptor signaling pathway [IMP]
- intracellular signal transduction [IDA]
- long-term memory [IMP]
- long-term synaptic potentiation [IMP]
- membrane depolarization [IMP]
- membrane hyperpolarization [IMP]
- microtubule cytoskeleton organization [ISO]
- negative regulation of apoptotic process [IDA]
- negative regulation of hydrolase activity [IDA]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- negative regulation of protein complex assembly [ISO]
- neuron projection extension [ISO]
- peptidyl-serine phosphorylation [IDA, ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO, ISS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of T-helper 2 cell cytokine production [ISO, ISS]
- positive regulation of T-helper 2 cell differentiation [ISO, ISS]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- positive regulation of glucose import [IMP]
- positive regulation of insulin receptor signaling pathway [IMP]
- positive regulation of interleukin-10 secretion [ISO, ISS]
- positive regulation of interleukin-13 secretion [ISO, ISS]
- positive regulation of interleukin-4 production [ISO, ISS]
- positive regulation of interleukin-5 secretion [ISO, ISS]
- positive regulation of protein transport [IMP]
- positive regulation of synaptic transmission [IMP]
- protein heterooligomerization [IPI]
- protein kinase C signaling [IMP]
- protein localization to plasma membrane [ISO]
- protein phosphorylation [IDA, ISO]
- signal transduction [IDA]
- vesicle transport along microtubule [IMP]
Gene Ontology Molecular Function- 14-3-3 protein binding [IPI]
- ATP binding [IDA]
- phospholipase binding [IPI]
- potassium channel regulator activity [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase C activity [IDA]
- protein kinase activity [ISO, TAS]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO]
- 14-3-3 protein binding [IPI]
- ATP binding [IDA]
- phospholipase binding [IPI]
- potassium channel regulator activity [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase C activity [IDA]
- protein kinase activity [ISO, TAS]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO]
Gene Ontology Cellular Component
- apical cortex [ISO]
- apical plasma membrane [ISO]
- axon hillock [ISO]
- cell cortex [ISO]
- cell leading edge [IDA]
- cell-cell junction [ISO, ISS]
- cytoplasm [IDA, ISO]
- cytosol [IDA, TAS]
- extracellular vesicular exosome [ISO]
- filamentous actin [IDA]
- intracellular membrane-bounded organelle [IDA]
- membrane raft [IDA]
- microtubule organizing center [ISO]
- myelin sheath abaxonal region [ISO]
- nuclear envelope [ISO]
- nuclear matrix [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
- protein complex [IDA, ISO]
- tight junction [ISO]
Rattus norvegicus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Phosphorylation of GAP-43 (growth-associated protein of 43 kDa) by conventional, novel and atypical isotypes of the protein kinase C gene family: differences between oligopeptide and polypeptide phosphorylation.
GAP-43 (growth-associated protein of 43 kDa; also known as neuromodulin, P-57, B-50 and F-1) is a neuronal calmodulin binding protein and a major protein kinase C (PKC) substrate in mammalian brain. Here we describe the phosphorylation by and the site specificity of different PKC isotypes. The conventional PKC beta 1 and the novel PKCs delta and epsilon effectively phosphorylated recombinant ... [more]
Biochem. J. Jul. 01, 1996; 317(0);219-24 [Pubmed: 8694767]
Throughput
- Low Throughput
Curated By
- BioGRID