BAIT
RAF1
clr8, cmc1, dos1, SPCC613.12c
CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1
GO Process (14)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
- cellular protein localization [IMP]
- chromatin silencing at centromere [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- chromatin silencing at telomere [IMP]
- chromatin silencing by small RNA [IMP]
- maintenance of chromatin silencing at silent mating-type cassette [NAS]
- meiotic chromosome segregation [IMP]
- meiotic sister chromatid cohesion, centromeric [IMP]
- meiotic telomere clustering [IMP]
- mitotic sister chromatid segregation [IMP]
- negative regulation of histone H3-K4 methylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of histone H3-K9 methylation [IMP]
- regulation of mating type switching [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
MIS6
SPAC1687.20c
inner centromere protein, CENP-I ortholog Mis6
GO Process (4)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Cell cycle-dependent deposition of CENP-A requires the Dos1/2-Cdc20 complex.
Centromeric histone CENP-A, a variant of canonical histone H3, plays a central role in proper chromosome segregation. Loading of CENP-A at centromeres is cell cycle-regulated: parental CENP-A is deposited at centromeres during S phase, whereas newly synthesized CENP-A is deposited during later stages of the cell cycle. The mechanisms involved in deposition of CENP-A at centromeres during S phase remain ... [more]
Proc. Natl. Acad. Sci. U.S.A. Dec. 24, 2012; 0(0); [Pubmed: 23267073]
Throughput
- Low Throughput
Ontology Terms
- phenotype: heat sensitivity (APO:0000147)
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID