USH2A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical plasma membrane [IDA]
- basement membrane [IDA, ISO]
- cytoplasm [ISO]
- neuronal cell body [ISO]
- periciliary membrane compartment [IDA]
- photoreceptor connecting cilium [IDA, ISO]
- photoreceptor inner segment [IDA, ISO]
- stereocilia ankle link [NAS]
- stereocilia ankle link complex [IDA]
- stereocilium [ISO]
- stereocilium bundle [IDA]
- stereocilium membrane [IDA]
- synapse [ISO]
- terminal bouton [ISO]
MYO7A
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- actin filament-based movement [ISO]
- auditory receptor cell differentiation [IMP]
- auditory receptor cell stereocilium organization [IMP]
- cell projection organization [IMP]
- equilibrioception [ISO]
- inner ear development [IMP]
- inner ear morphogenesis [IMP]
- inner ear receptor cell differentiation [IMP]
- intracellular protein transport [IMP]
- lysosome organization [ISO]
- mechanoreceptor differentiation [IMP]
- phagocytosis [IMP]
- phagolysosome assembly [IMP]
- pigment granule localization [IMP]
- pigment granule transport [IMP]
- post-embryonic organ morphogenesis [IMP]
- sensory perception [IMP]
- sensory perception of light stimulus [IMP, ISO]
- sensory perception of sound [IMP, ISO]
- visual perception [IMP, ISO]
Gene Ontology Molecular Function- ADP binding [ISO]
- ATP binding [ISO]
- actin binding [ISO]
- actin filament binding [ISO]
- actin-dependent ATPase activity [ISO]
- calmodulin binding [ISO]
- microfilament motor activity [ISO]
- motor activity [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [IPI]
- protein homodimerization activity [ISO]
- spectrin binding [ISO]
- ADP binding [ISO]
- ATP binding [ISO]
- actin binding [ISO]
- actin filament binding [ISO]
- actin-dependent ATPase activity [ISO]
- calmodulin binding [ISO]
- microfilament motor activity [ISO]
- motor activity [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [IPI]
- protein homodimerization activity [ISO]
- spectrin binding [ISO]
Gene Ontology Cellular Component
- apical plasma membrane [IDA]
- cell [IMP]
- cytoplasm [IDA, ISA, ISO]
- cytosol [ISO]
- intracellular [IMP]
- lysosomal membrane [ISO]
- melanosome [IDA]
- microvillus [ISA]
- myosin VII complex [ISO]
- myosin complex [ISO]
- photoreceptor connecting cilium [IDA]
- photoreceptor inner segment [IDA]
- photoreceptor outer segment [IDA]
- stereocilium [IDA]
- synapse [IDA]
- upper tip-link density [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.
Several lines of evidence indicate that very large G-protein-coupled receptor 1 (Vlgr1) makes up the ankle links that connect the stereocilia of hair cells at their base. Here, we show that the transmembrane protein usherin, the putative transmembrane protein vezatin, and the PDZ (postsynaptic density-95/Discs large/zona occludens-1) domain-containing submembrane protein whirlin are colocalized with Vlgr1 at the stereocilia base in ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID