MIB1
Gene Ontology Biological Process
- Notch signaling pathway [IMP]
- blood vessel development [IMP]
- heart development [IMP]
- heart looping [IMP]
- in utero embryonic development [IMP]
- negative regulation of neuron differentiation [IMP]
- neural tube formation [IMP]
- positive regulation of endocytosis [IDA]
- protein ubiquitination [IBA]
- somitogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DLL1
Gene Ontology Biological Process
- Notch signaling involved in heart development [IC]
- Notch signaling pathway [ISO, TAS]
- auditory receptor cell differentiation [NAS]
- auditory receptor cell fate commitment [NAS]
- cell-cell signaling [IDA]
- compartment pattern specification [IMP]
- determination of left/right symmetry [IMP]
- heart looping [IMP]
- in utero embryonic development [NAS]
- inner ear development [IMP]
- inner ear morphogenesis [NAS]
- left/right axis specification [IMP]
- negative regulation of auditory receptor cell differentiation [IMP]
- negative regulation of cell differentiation [IMP]
- negative regulation of interleukin-10 production [ISO]
- negative regulation of myeloid cell differentiation [IDA]
- negative regulation of neuron differentiation [IMP]
- nervous system development [NAS]
- odontogenesis of dentin-containing tooth [NAS]
- organ morphogenesis [NAS]
- positive regulation of Notch signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of neurogenesis [IMP]
- somite specification [IMP]
- somitogenesis [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Mind bomb 1 is essential for generating functional Notch ligands to activate Notch.
The Delta-Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism essential for cell fate specification. Mind bomb 1 (Mib1) has been identified as a ubiquitin ligase that promotes the endocytosis of Delta. We now report that mice lacking Mib1 die prior to embryonic day 11.5, with pan-Notch defects in somitogenesis, neurogenesis, vasculogenesis and cardiogenesis. The Mib1-/- embryos exhibit reduced ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DLL1 MIB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID