MIB1
Gene Ontology Biological Process
- Notch signaling pathway [IMP]
- blood vessel development [IMP]
- heart development [IMP]
- heart looping [IMP]
- in utero embryonic development [IMP]
- negative regulation of neuron differentiation [IMP]
- neural tube formation [IMP]
- positive regulation of endocytosis [IDA]
- protein ubiquitination [IBA]
- somitogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DLL4
Gene Ontology Biological Process
- Notch signaling involved in heart development [IMP]
- angiogenesis [IMP]
- blood vessel lumenization [IMP]
- blood vessel remodeling [IMP]
- cardiac atrium morphogenesis [IMP]
- cardiac ventricle morphogenesis [IMP]
- cellular response to fibroblast growth factor stimulus [ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- dorsal aorta morphogenesis [IMP]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [ISO]
- negative regulation of cell migration involved in sprouting angiogenesis [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of endothelial cell migration [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- patterning of blood vessels [IMP]
- pericardium morphogenesis [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of neural precursor cell proliferation [IMP]
- regulation of neural retina development [IMP]
- regulation of neurogenesis [IMP]
- ventral spinal cord interneuron fate commitment [ISO]
- ventricular trabecula myocardium morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Mind bomb 1 is essential for generating functional Notch ligands to activate Notch.
The Delta-Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism essential for cell fate specification. Mind bomb 1 (Mib1) has been identified as a ubiquitin ligase that promotes the endocytosis of Delta. We now report that mice lacking Mib1 die prior to embryonic day 11.5, with pan-Notch defects in somitogenesis, neurogenesis, vasculogenesis and cardiogenesis. The Mib1-/- embryos exhibit reduced ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
DLL4 MIB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID