MIB1
Gene Ontology Biological Process
- Notch signaling pathway [IMP]
- blood vessel development [IMP]
- heart development [IMP]
- heart looping [IMP]
- in utero embryonic development [IMP]
- negative regulation of neuron differentiation [IMP]
- neural tube formation [IMP]
- positive regulation of endocytosis [IDA]
- protein ubiquitination [IBA]
- somitogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
JAG1
Gene Ontology Biological Process
- Notch signaling involved in heart development [IMP, ISO]
- Notch signaling pathway [ISO, TAS]
- T cell mediated immunity [ISO]
- aorta morphogenesis [IMP]
- auditory receptor cell differentiation [IMP, ISO]
- blood vessel remodeling [IMP]
- camera-type eye development [IMP]
- cardiac neural crest cell development involved in outflow tract morphogenesis [IMP]
- cardiac right ventricle morphogenesis [IMP]
- cardiac septum morphogenesis [IMP]
- ciliary body morphogenesis [IMP]
- endocardial cushion cell development [IMP]
- inner ear development [IMP]
- morphogenesis of an epithelial sheet [IMP]
- negative regulation of cell differentiation [IMP, ISO]
- negative regulation of fat cell differentiation [IDA]
- negative regulation of neuron differentiation [IMP]
- negative regulation of stem cell differentiation [ISO]
- organ morphogenesis [IMP]
- positive regulation of Notch signaling pathway [IDA]
- positive regulation of myeloid cell differentiation [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- pulmonary artery morphogenesis [ISO]
- pulmonary valve morphogenesis [ISO]
- regulation of cell proliferation [ISO]
- response to muramyl dipeptide [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Mind bomb 1 is essential for generating functional Notch ligands to activate Notch.
The Delta-Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism essential for cell fate specification. Mind bomb 1 (Mib1) has been identified as a ubiquitin ligase that promotes the endocytosis of Delta. We now report that mice lacking Mib1 die prior to embryonic day 11.5, with pan-Notch defects in somitogenesis, neurogenesis, vasculogenesis and cardiogenesis. The Mib1-/- embryos exhibit reduced ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID