MIB1
Gene Ontology Biological Process
- Notch signaling pathway [IMP]
- blood vessel development [IMP]
- heart development [IMP]
- heart looping [IMP]
- in utero embryonic development [IMP]
- negative regulation of neuron differentiation [IMP]
- neural tube formation [IMP]
- positive regulation of endocytosis [IDA]
- protein ubiquitination [IBA]
- somitogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
JAG2
Gene Ontology Biological Process
- T cell differentiation [ISO]
- auditory receptor cell fate commitment [IMP]
- cell differentiation [ISO]
- cell fate determination [NAS]
- epithelial cell apoptotic process involved in palatal shelf morphogenesis [IMP]
- gamma-delta T cell differentiation [IMP]
- in utero embryonic development [IMP]
- morphogenesis of embryonic epithelium [IMP]
- odontogenesis of dentin-containing tooth [IMP]
- regulation of cell adhesion [IMP]
- regulation of cell proliferation [ISO, ISS]
- respiratory system process [IMP]
- sensory perception of sound [NAS]
- skeletal system development [IMP]
- spermatogenesis [ISO]
- thymic T cell selection [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Mind bomb 1 is essential for generating functional Notch ligands to activate Notch.
The Delta-Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism essential for cell fate specification. Mind bomb 1 (Mib1) has been identified as a ubiquitin ligase that promotes the endocytosis of Delta. We now report that mice lacking Mib1 die prior to embryonic day 11.5, with pan-Notch defects in somitogenesis, neurogenesis, vasculogenesis and cardiogenesis. The Mib1-/- embryos exhibit reduced ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID