EGR2
Gene Ontology Biological Process
- Schwann cell differentiation [IMP]
- brain segmentation [IMP]
- cellular response to cAMP [IBA]
- cellular response to gonadotropin stimulus [IBA]
- cellular response to organic substance [IDA]
- facial nerve structural organization [IGI]
- fat cell differentiation [IMP]
- motor neuron axon guidance [IGI]
- myelination [IMP]
- negative regulation of apoptotic process [IBA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- protein export from nucleus [IDA]
- regulation of neuronal synaptic plasticity [IBA]
- regulation of ossification [IMP]
- regulation of transcription, DNA-templated [IMP]
- response to insulin [ISO]
- rhombomere 3 development [IGI]
- rhombomere 3 formation [IMP]
- rhombomere 5 formation [IMP]
- rhythmic behavior [IDA, IMP]
- skeletal muscle cell differentiation [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- HMG box domain binding [ISO]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, IMP, ISO]
- transcription regulatory region DNA binding [IDA]
- ubiquitin protein ligase binding [ISO]
- DNA binding [IDA]
- HMG box domain binding [ISO]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, IMP, ISO]
- transcription regulatory region DNA binding [IDA]
- ubiquitin protein ligase binding [ISO]
PIAS2
Gene Ontology Biological Process
- androgen receptor signaling pathway [ISO]
- negative regulation of androgen receptor signaling pathway [ISO]
- positive regulation of dendrite morphogenesis [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- protein sumoylation [IDA, ISO]
- regulation of androgen receptor signaling pathway [ISO]
- regulation of osteoblast differentiation [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [ISO]
- transcription, DNA-templated [IDA]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
PIASxbeta acts as an activator of Hoxb1 and is antagonized by Krox20 during hindbrain segmentation.
The zinc-finger transcription factor Krox20 constitutes a key regulator of hindbrain development, essential for the formation and specification of rhombomeres (r) 3 and 5. It is in particular responsible for the respective activation and repression of odd- and even-numbered rhombomere-specific genes, which include Hox genes. In this study, we have identified PIASxbeta as a novel direct interactor of Krox20. In ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID