SDO1
Gene Ontology Biological Process
Gene Ontology Molecular Function
SKI8
Gene Ontology Biological Process
- nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [IGI, IMP]
- nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [IMP]
- nuclear-transcribed mRNA catabolic process, non-stop decay [IMP]
- protein complex assembly [IMP]
- protein-DNA complex assembly [IMP]
- reciprocal meiotic recombination [IGI, IMP, IPI]
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.
Removal of the assembly factor eukaryotic initiation factor 6 (eIF6) is critical for late cytoplasmic maturation of 60S ribosomal subunits. In mammalian cells, the current model posits that eIF6 release is triggered following phosphorylation of Ser 235 by activated protein kinase C. In contrast, genetic studies in yeast indicate a requirement for the ortholog of the SBDS (Shwachman-Bodian-Diamond syndrome) gene ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- Interaction confirmed by tetrad analysis or random spore analysis; growth defect seen in triple mutant: sdo1 (deletion) TIF6 (dominant mutation) hit gene (deletion)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SDO1 SKI8 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2495 | BioGRID | 1999180 | |
| SKI8 SDO1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2289 | BioGRID | 2043986 | |
| SKI8 SDO1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1021 | BioGRID | 2429734 |
Curated By
- BioGRID