DNMT3A
Gene Ontology Biological Process
- C-5 methylation of cytosine [IGI, ISO]
- DNA methylation [IDA, IGI, ISO]
- DNA methylation involved in embryo development [IMP]
- DNA methylation involved in gamete generation [IMP]
- DNA methylation on cytosine [ISO]
- DNA methylation on cytosine within a CG sequence [ISO]
- S-adenosylhomocysteine metabolic process [ISO]
- S-adenosylmethioninamine metabolic process [ISO]
- cellular response to amino acid stimulus [IDA]
- hypermethylation of CpG island [IDA]
- maintenance of DNA methylation [TAS]
- methylation [TAS]
- methylation-dependent chromatin silencing [IDA, IGI]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of cell death [ISO]
- regulation of gene expression by genetic imprinting [IDA, IMP]
- spermatogenesis [IMP]
Gene Ontology Molecular Function- DNA (cytosine-5-)-methyltransferase activity [IDA, IGI, ISO]
- DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [ISO]
- DNA binding [IDA, ISO]
- chromatin binding [IDA, ISO]
- identical protein binding [ISO]
- methyltransferase activity [TAS]
- protein binding [IPI]
- unmethylated CpG binding [ISO]
- DNA (cytosine-5-)-methyltransferase activity [IDA, IGI, ISO]
- DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [ISO]
- DNA binding [IDA, ISO]
- chromatin binding [IDA, ISO]
- identical protein binding [ISO]
- methyltransferase activity [TAS]
- protein binding [IPI]
- unmethylated CpG binding [ISO]
Gene Ontology Cellular Component
EHMT2
Gene Ontology Biological Process
- DNA methylation [IDA]
- DNA methylation on cytosine within a CG sequence [IMP]
- cellular response to drug [ISO]
- fertilization [IMP]
- germ cell development [IMP]
- histone H3-K27 methylation [IDA, IMP]
- histone H3-K9 methylation [IDA, IMP]
- histone lysine methylation [ISO]
- histone methylation [IMP, ISO]
- long-term memory [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- organ growth [IMP]
- peptidyl-lysine dimethylation [ISO]
- peptidyl-lysine methylation [IMP]
- regulation of DNA methylation [ISO]
- regulation of DNA replication [IMP, ISO]
- regulation of histone H3-K4 methylation [ISO]
- regulation of histone H3-K9 methylation [ISO]
- regulation of transcription from RNA polymerase II promoter [IMP]
- spermatid development [IMP]
- synaptonemal complex assembly [IMP]
Gene Ontology Molecular Function- C2H2 zinc finger domain binding [IPI, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- histone methyltransferase activity (H3-K27 specific) [IDA]
- histone methyltransferase activity (H3-K9 specific) [IDA, IMP]
- histone-lysine N-methyltransferase activity [IDA, IMP, ISO]
- p53 binding [ISO]
- protein binding [IPI]
- protein-lysine N-methyltransferase activity [ISO]
- C2H2 zinc finger domain binding [IPI, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- histone methyltransferase activity (H3-K27 specific) [IDA]
- histone methyltransferase activity (H3-K9 specific) [IDA, IMP]
- histone-lysine N-methyltransferase activity [IDA, IMP, ISO]
- p53 binding [ISO]
- protein binding [IPI]
- protein-lysine N-methyltransferase activity [ISO]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes.
The pluripotency-determining gene Oct3/4 (also called Pou5f1) undergoes postimplantation silencing in a process mediated by the histone methyltransferase G9a. Microarray analysis now shows that this enzyme may operate as a master regulator that inactivates numerous early-embryonic genes by bringing about heterochromatinization of methylated histone H3K9 and de novo DNA methylation. Genetic studies in differentiating embryonic stem cells demonstrate that a ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| EHMT2 DNMT3A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID