BAIT
NREP
AI325076, D0H4S114, Harp, P311, PTZ17, SEZ17
neuronal regeneration related protein
GO Process (2)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
TGFB1
TGF-beta1, TGFbeta1, Tgfb, Tgfb-1
transforming growth factor, beta 1
GO Process (138)
GO Function (10)
GO Component (11)
Gene Ontology Biological Process
- ATP biosynthetic process [ISO]
- MAPK cascade [ISO]
- SMAD protein complex assembly [ISO]
- SMAD protein import into nucleus [ISO]
- SMAD protein signal transduction [IBA]
- T cell activation [IDA, IMP]
- T cell differentiation [IMP]
- T cell homeostasis [IMP]
- adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [IDA]
- branch elongation involved in mammary gland duct branching [IMP]
- cell activation [IDA]
- cell cycle arrest [ISO]
- cell proliferation [IDA, TAS]
- cell-cell junction organization [ISO]
- cellular calcium ion homeostasis [IMP]
- cellular response to dexamethasone stimulus [ISO]
- cellular response to growth factor stimulus [IDA]
- cellular response to organic cyclic compound [ISO]
- cellular response to transforming growth factor beta stimulus [IDA, ISO]
- chondrocyte differentiation [ISO]
- common-partner SMAD protein phosphorylation [ISO]
- defense response [TAS]
- defense response to fungus, incompatible interaction [ISO]
- endoderm development [IDA]
- epidermal growth factor receptor signaling pathway [ISO]
- epithelial to mesenchymal transition [ISO]
- evasion or tolerance of host defenses by virus [ISO]
- extracellular matrix assembly [IDA, ISO]
- extrinsic apoptotic signaling pathway [ISO]
- germ cell migration [IDA]
- hematopoietic progenitor cell differentiation [ISO]
- hyaluronan catabolic process [ISO]
- inflammatory response [IMP, ISO]
- lens fiber cell differentiation [IMP]
- lipopolysaccharide-mediated signaling pathway [ISO]
- lymph node development [IMP]
- mammary gland branching involved in thelarche [IMP]
- mammary gland development [IDA]
- mitotic cell cycle checkpoint [ISO]
- mononuclear cell proliferation [IMP]
- morphogenesis of a branching structure [ISO]
- myelination [ISO]
- myeloid dendritic cell differentiation [IMP]
- negative regulation of DNA replication [ISO]
- negative regulation of T cell activation [IMP]
- negative regulation of T cell proliferation [IMP]
- negative regulation of blood vessel endothelial cell migration [ISO]
- negative regulation of cell cycle [ISO]
- negative regulation of cell growth [IDA, ISO]
- negative regulation of cell proliferation [ISO, TAS]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of fat cell differentiation [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of hyaluronan biosynthetic process [ISO]
- negative regulation of immune response [ISO]
- negative regulation of macrophage cytokine production [ISO]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of myoblast differentiation [ISO]
- negative regulation of neuroblast proliferation [ISO]
- negative regulation of ossification [IDA]
- negative regulation of phagocytosis [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of release of sequestered calcium ion into cytosol [ISO]
- negative regulation of skeletal muscle tissue development [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- negative regulation of transcription, DNA-templated [ISO]
- organ morphogenesis [TAS]
- organ regeneration [ISO]
- pathway-restricted SMAD protein phosphorylation [IDA, ISO]
- phosphate-containing compound metabolic process [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of NAD+ ADP-ribosyltransferase activity [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of SMAD protein import into nucleus [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of branching involved in ureteric bud morphogenesis [ISO]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IDA, ISO]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of chemotaxis [ISO]
- positive regulation of collagen biosynthetic process [IDA, ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of epithelial to mesenchymal transition [IDA, ISO]
- positive regulation of exit from mitosis [ISO]
- positive regulation of fibroblast migration [ISO]
- positive regulation of gene expression [IDA, ISO]
- positive regulation of histone acetylation [IDA]
- positive regulation of histone deacetylation [IDA]
- positive regulation of interleukin-17 production [IDA, ISO]
- positive regulation of isotype switching to IgA isotypes [ISO]
- positive regulation of odontogenesis [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IBA, ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of protein complex assembly [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of protein import into nucleus [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein localization to nucleus [IGI]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein secretion [ISO]
- positive regulation of smooth muscle cell differentiation [ISO]
- positive regulation of superoxide anion generation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription regulatory region DNA binding [ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- protein export from nucleus [ISO]
- protein import into nucleus, translocation [ISO]
- protein kinase B signaling [ISO]
- protein phosphorylation [IDA, IGI]
- receptor catabolic process [ISO]
- regulation of DNA binding [IDA]
- regulation of MAPK cascade [IBA]
- regulation of actin cytoskeleton reorganization [IGI]
- regulation of apoptotic process [IBA]
- regulation of binding [IDA]
- regulation of branching involved in mammary gland duct morphogenesis [IGI]
- regulation of cartilage development [IDA]
- regulation of cell proliferation [IDA]
- regulation of miRNA metabolic process [ISO]
- regulation of protein import into nucleus [IDA]
- regulation of sodium ion transport [IDA]
- regulation of striated muscle tissue development [IDA]
- regulation of transforming growth factor beta receptor signaling pathway [ISO]
- regulatory T cell differentiation [IDA, IMP]
- response to cholesterol [ISO]
- response to estradiol [ISO]
- response to organic substance [ISO]
- response to progesterone [ISO]
- skeletal muscle tissue development [TAS]
- skeletal system development [TAS]
- tolerance induction to self antigen [IMP]
- transforming growth factor beta receptor signaling pathway [IDA, ISO]
- wound healing [ISO]
Gene Ontology Molecular Function- antigen binding [ISO]
- cytokine activity [IBA]
- enzyme binding [ISO]
- glycoprotein binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- transforming growth factor beta receptor binding [IPI, TAS]
- type II transforming growth factor beta receptor binding [IBA, ISO]
- antigen binding [ISO]
- cytokine activity [IBA]
- enzyme binding [ISO]
- glycoprotein binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- transforming growth factor beta receptor binding [IPI, TAS]
- type II transforming growth factor beta receptor binding [IBA, ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2.
P311 is an 8-kDa protein originally found in neurons and muscle. We recently showed that expression of P311 in NIH 3T3 cells induced a myofibroblast phenotype with low TGF-beta1 expression. Here we demonstrate that P311 downregulates not only TGF-beta1, but also TGF-beta2, expression, with no effect on TGF-beta3. In addition, P311 interacts with TGF-beta2 in a yeast two-hybrid system through ... [more]
Biochem. Biophys. Res. Commun. Mar. 19, 2004; 315(4);1104-9 [Pubmed: 14985127]
Throughput
- Low Throughput
Curated By
- BioGRID