BAIT
NREP
AI325076, D0H4S114, Harp, P311, PTZ17, SEZ17
neuronal regeneration related protein
GO Process (2)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
TGFB2
BB105277, Tgf-beta2, Tgfb-2
transforming growth factor, beta 2
GO Process (83)
GO Function (11)
GO Component (11)
Gene Ontology Biological Process
- SMAD protein import into nucleus [ISO]
- SMAD protein signal transduction [IBA]
- activation of protein kinase activity [ISO]
- axon guidance [IMP]
- blood vessel development [IMP]
- blood vessel remodeling [IMP]
- cardiac epithelial to mesenchymal transition [ISO]
- cardiac left ventricle morphogenesis [TAS]
- cardiac muscle cell proliferation [ISO]
- cardiac right ventricle morphogenesis [TAS]
- cardioblast differentiation [ISO]
- cartilage condensation [IGI]
- catagen [ISO]
- cell cycle arrest [ISO]
- cell death [ISO]
- cell migration [ISO]
- cell morphogenesis [ISO]
- cell-cell junction organization [ISO]
- collagen fibril organization [ISO]
- dopamine biosynthetic process [IMP]
- embryonic neurocranium morphogenesis [ISO]
- epithelial to mesenchymal transition [ISO]
- extracellular matrix organization [IMP]
- extrinsic apoptotic signaling pathway [ISO]
- eye development [ISO]
- glial cell migration [ISO]
- hair follicle development [IMP, ISO]
- hair follicle morphogenesis [IMP]
- heart development [IMP, ISO]
- heart morphogenesis [ISO]
- heart valve morphogenesis [IMP]
- hemopoiesis [IMP]
- intracellular signal transduction [ISO]
- negative regulation of alkaline phosphatase activity [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cartilage development [IMP]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of immune response [ISO]
- negative regulation of keratinocyte differentiation [NAS]
- negative regulation of macrophage cytokine production [ISO]
- negative regulation of release of sequestered calcium ion into cytosol [ISO]
- neuron development [IMP]
- neuron fate commitment [IDA]
- outflow tract morphogenesis [TAS]
- pathway-restricted SMAD protein phosphorylation [IDA, ISO]
- positive regulation of activation-induced cell death of T cells [IDA]
- positive regulation of apoptotic process [ISO]
- positive regulation of cardioblast differentiation [ISO]
- positive regulation of catagen [ISO]
- positive regulation of cell adhesion mediated by integrin [ISO]
- positive regulation of cell cycle [IMP]
- positive regulation of cell growth [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of heart contraction [ISO]
- positive regulation of integrin biosynthetic process [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IBA]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein secretion [ISO]
- positive regulation of stress-activated MAPK cascade [ISO]
- protein phosphorylation [ISO]
- regulation of MAPK cascade [IBA]
- regulation of apoptotic process [IMP]
- regulation of cell proliferation [IBA]
- regulation of extracellular matrix organization [IMP]
- regulation of transforming growth factor beta2 production [ISO]
- response to drug [ISO]
- response to estrogen [ISO]
- response to hypoxia [ISO]
- response to progesterone [ISO]
- signal transduction by phosphorylation [ISO]
- skeletal system development [IMP]
- somatic stem cell division [IDA]
- transforming growth factor beta receptor signaling pathway [IBA, ISO]
- ventricular septum morphogenesis [TAS]
- wound healing [ISO]
Gene Ontology Molecular Function- beta-amyloid binding [ISO]
- cytokine activity [IBA]
- growth factor activity [TAS]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- receptor signaling protein serine/threonine kinase activity [ISO]
- transforming growth factor beta receptor binding [ISO]
- type II transforming growth factor beta receptor binding [IBA, ISO]
- beta-amyloid binding [ISO]
- cytokine activity [IBA]
- growth factor activity [TAS]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- receptor signaling protein serine/threonine kinase activity [ISO]
- transforming growth factor beta receptor binding [ISO]
- type II transforming growth factor beta receptor binding [IBA, ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2.
P311 is an 8-kDa protein originally found in neurons and muscle. We recently showed that expression of P311 in NIH 3T3 cells induced a myofibroblast phenotype with low TGF-beta1 expression. Here we demonstrate that P311 downregulates not only TGF-beta1, but also TGF-beta2, expression, with no effect on TGF-beta3. In addition, P311 interacts with TGF-beta2 in a yeast two-hybrid system through ... [more]
Biochem. Biophys. Res. Commun. Mar. 19, 2004; 315(4);1104-9 [Pubmed: 14985127]
Throughput
- Low Throughput
Curated By
- BioGRID