BAIT
CER1
Cerl, Cerl1, Cerr1, cer-1, RP23-410K19.2
cerberus 1 homolog (Xenopus laevis)
GO Process (16)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- anterior/posterior axis specification [IDA, IGI]
- anterior/posterior pattern specification [IDA]
- bone mineralization [ISO]
- cell migration involved in gastrulation [IGI]
- cellular response to BMP stimulus [ISS]
- determination of dorsal identity [ISO]
- gastrulation [IGI]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of activin receptor signaling pathway [IDA, ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of mesoderm development [IDA, ISO]
- nervous system development [ISO]
- sequestering of BMP in extracellular matrix [IDA, ISO]
- signal transduction involved in regulation of gene expression [IDA]
- ureteric bud development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NODAL
Tg.413d
nodal
GO Process (72)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- SMAD protein signal transduction [IDA]
- anatomical structure formation involved in morphogenesis [IMP]
- anterior/posterior axis specification [IMP]
- anterior/posterior pattern specification [IGI, IMP]
- axial mesodermal cell fate specification [IMP]
- brain development [IMP]
- cell fate commitment [IMP]
- cell migration [IMP]
- cell migration involved in gastrulation [IDA]
- determination of left/right symmetry [IDA, IGI, IMP, TAS]
- digestive system development [IMP]
- digestive tract morphogenesis [IMP]
- embryonic cranial skeleton morphogenesis [IMP]
- embryonic heart tube development [IMP]
- embryonic pattern specification [IMP]
- embryonic placenta development [IMP]
- embryonic process involved in female pregnancy [IMP]
- endoderm development [IMP]
- endodermal cell differentiation [ISO]
- epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification [IMP]
- floor plate morphogenesis [IMP]
- formation of anatomical boundary [IMP]
- gastrulation [IMP]
- gastrulation with mouth forming second [IMP]
- heart development [IMP]
- heart looping [IGI]
- in utero embryonic development [IMP]
- inhibition of neuroepithelial cell differentiation [IMP]
- left lung morphogenesis [IMP]
- liver development [IMP]
- lung development [IMP]
- maternal placenta development [IMP]
- maternal process involved in parturition [IMP]
- mesendoderm development [IMP, ISO]
- mesoderm formation [IMP, TAS]
- negative regulation of androgen receptor signaling pathway [ISO]
- negative regulation of cell development [IMP]
- negative regulation of cell differentiation [IDA]
- negative regulation of chorionic trophoblast cell proliferation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of trophoblast cell migration [ISO]
- nervous system development [IMP]
- neural fold formation [IMP]
- nodal signaling pathway [IMP]
- nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [IMP]
- placenta development [ISO]
- polarity specification of proximal/distal axis [IMP]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of SMAD protein import into nucleus [ISO]
- positive regulation of activin receptor signaling pathway [ISO]
- positive regulation of angiogenesis [IMP, ISO]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell-cell adhesion [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IBA, ISO]
- positive regulation of receptor activity [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation vascular endothelial growth factor production [ISO]
- primitive streak formation [IGI]
- regulation of MAPK cascade [IBA]
- regulation of apoptotic process [IBA]
- regulation of gastrulation [IGI]
- regulation of signal transduction [IDA]
- stem cell maintenance [IGI, IMP]
- tissue morphogenesis [IMP]
- transforming growth factor beta receptor signaling pathway [ISA]
- transforming growth factor beta receptor signaling pathway involved in primitive streak formation [IMP]
- trophectodermal cell differentiation [IDA]
- trophectodermal cellular morphogenesis [IMP]
- vasculature development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis.
Correct establishment of the left/right (L/R) body asymmetry in the mouse embryo requires asymmetric activation of the evolutionarily conserved Nodal signaling cascade in the left lateral plate mesoderm (L-LPM). Furthermore, the presence of Nodal in the node is essential for its own expression in the L-LPM. Here, we have characterized the function of cerl-2, a novel Nodal antagonist, which displays ... [more]
Genes Dev. Oct. 01, 2004; 18(19);2342-7 [Pubmed: 15466485]
Throughput
- Low Throughput
Curated By
- BioGRID