BAIT

CRB2

rhp9, SPBC342.05
DNA repair protein Rad9 homolog, Rhp9
GO Process (1)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)
PREY

PCN1

pcn, SPBC16D10.09
PCNA
GO Process (2)
GO Function (2)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

The S/M checkpoint at 37 degrees C and the recovery of viability of the mutant poldeltats3 require the crb2+/rhp9+ gene in fission yeast.

Grenon M, Tillit J, Piard K, Baldacci G, Francesconi S

We have isolated a mutant in fission yeast, in which mitosis is uncoupled from completion of DNA replication when DNA synthesis is impaired by a thermosensitive mutation in the gene encoding the catalytic subunit of DNA polymerase delta. By functional complementation, we cloned the wild-type gene and identified it as the recently cloned checkpoint gene crb2+/rhp9+. This gene has been ... [more]

Mol. Gen. Genet. Jan. 01, 1999; 260(6);522-34 [Pubmed: 9928931]

Throughput

  • Low Throughput

Ontology Terms

  • mitotic cell cycle (APO:0000072)

Additional Notes

  • overexpression of pcn1 in a crb2 or chk1 mutant background results in the cut phenotype, indicating lethal entry into mitosis

Curated By

  • BioGRID