BAIT
CDK1
CDC2, CDC28A, P34CDC2
cyclin-dependent kinase 1
GO Process (46)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- DNA repair [TAS]
- DNA replication [TAS]
- Fc-epsilon receptor signaling pathway [TAS]
- G1/S transition of mitotic cell cycle [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- MAPK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- Ras protein signal transduction [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- activation of MAPKK activity [TAS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- axon guidance [TAS]
- cell migration [TAS]
- centrosome cycle [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- epithelial cell differentiation [IEP]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- microtubule cytoskeleton organization [TAS]
- mitotic cell cycle [TAS]
- mitotic nuclear envelope disassembly [TAS]
- negative regulation of apoptotic process [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- pronuclear fusion [TAS]
- protein localization to kinetochore [IDA]
- regulation of Schwann cell differentiation [TAS]
- regulation of embryonic development [TAS]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [TAS]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- small GTPase mediated signal transduction [TAS]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RARA
Nr1b1, RAR, RARalpha1, RP23-333D2.3
retinoic acid receptor, alpha
GO Process (61)
GO Function (26)
GO Component (8)
Gene Ontology Biological Process
- Sertoli cell fate commitment [IMP]
- apoptotic cell clearance [ISO]
- bone development [IGI]
- cellular response to estrogen stimulus [ISO]
- cellular response to lipopolysaccharide [IDA]
- cellular response to retinoic acid [ISO]
- chondroblast differentiation [IMP]
- embryonic camera-type eye development [IGI]
- face development [IGI]
- germ cell development [IMP]
- glandular epithelial cell development [IGI]
- growth plate cartilage development [IGI]
- intracellular estrogen receptor signaling pathway [ISO]
- limb development [IGI]
- male gonad development [ISO]
- multicellular organism growth [IGI]
- negative regulation of apoptotic process [IGI]
- negative regulation of cartilage development [IMP]
- negative regulation of cell differentiation [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of gene expression [IGI]
- negative regulation of granulocyte differentiation [ISO]
- negative regulation of interferon-gamma production [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- negative regulation of translation [ISO]
- negative regulation of translational initiation [IDA]
- negative regulation of tumor necrosis factor production [ISO]
- neural tube closure [IGI]
- outflow tract septum morphogenesis [IGI]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of T-helper 2 cell differentiation [ISO]
- positive regulation of binding [ISO]
- positive regulation of cell cycle [ISO]
- positive regulation of cell proliferation [IGI, ISO]
- positive regulation of gene expression [IMP]
- positive regulation of interleukin-13 production [ISO]
- positive regulation of interleukin-4 production [ISO]
- positive regulation of interleukin-5 production [ISO]
- positive regulation of neuron differentiation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein phosphorylation [ISO]
- regulation of apoptotic process [ISO]
- regulation of granulocyte differentiation [IMP]
- regulation of myelination [ISO]
- regulation of phosphatidylinositol 3-kinase activity [ISO]
- regulation of synaptic plasticity [ISO]
- regulation of transcription, DNA-templated [IDA]
- response to estradiol [ISO]
- response to ethanol [ISO]
- response to retinoic acid [IMP, ISO]
- retinoic acid receptor signaling pathway [IDA, ISO]
- signal transduction [ISO]
- spermatogenesis [IMP]
- trachea cartilage development [IMP]
- transcription from RNA polymerase II promoter [IDA]
- ureteric bud development [IMP]
- ventricular cardiac muscle cell differentiation [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II regulatory region DNA binding [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- chromatin DNA binding [ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- mRNA 5'-UTR binding [ISO]
- phosphatidylinositol 3-kinase regulator activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase A binding [ISO]
- protein kinase B binding [ISO]
- receptor binding [ISO]
- retinoic acid binding [ISO]
- retinoic acid receptor activity [IDA, ISO]
- retinoic acid-responsive element binding [ISO]
- sequence-specific DNA binding [IDA, IGI]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription coactivator activity [ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [IMP]
- translation repressor activity, nucleic acid binding [ISO]
- DNA binding [IDA]
- RNA polymerase II regulatory region DNA binding [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- chromatin DNA binding [ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- mRNA 5'-UTR binding [ISO]
- phosphatidylinositol 3-kinase regulator activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase A binding [ISO]
- protein kinase B binding [ISO]
- receptor binding [ISO]
- retinoic acid binding [ISO]
- retinoic acid receptor activity [IDA, ISO]
- retinoic acid-responsive element binding [ISO]
- sequence-specific DNA binding [IDA, IGI]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription coactivator activity [ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [IMP]
- translation repressor activity, nucleic acid binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Hyperphosphorylation of the retinoid X receptor alpha by activated c-Jun NH2-terminal kinases.
The nuclear receptor mouse retinoid X receptor alpha (mRXRalpha) was shown to be constitutively phosphorylated in its NH2-terminal A/B region, which contains potential phosphorylation sites for proline-directed Ser/Thr kinases. Mutants for each putative site were generated and overexpressed in transfected COS-1 cells. Constitutively phosphorylated residues identified by tryptic phosphopeptide mapping included serine 22 located in the A1 region that is ... [more]
J. Biol. Chem. Jul. 02, 1999; 274(27);18932-41 [Pubmed: 10383391]
Throughput
- Low Throughput
Additional Notes
- figure 3.
Curated By
- BioGRID