FEM1B
Gene Ontology Biological Process
- branching involved in prostate gland morphogenesis [IMP]
- epithelial cell maturation [IMP]
- epithelial cell maturation involved in prostate gland development [IMP]
- protein ubiquitination [IDA, ISO]
- regulation of DNA damage checkpoint [ISO]
- regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- regulation of ubiquitin-protein transferase activity [ISO]
Gene Ontology Molecular Function
FEM1B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis.
Apoptosis is an evolutionarily conserved process that is critical for tissue homeostasis and development including sex determination in essentially all multicellular organisms. Here, we report the cloning of an ankyrin repeat-containing protein, termed F1Aalpha, in a yeast two-hybrid screen using the cytoplasmic domain of Fas (CD95/APO-1) as bait. Amino acid sequence analysis indicates that F1Aalpha has extensive homology to the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID