WHSC1
Gene Ontology Biological Process
- atrial septum primum morphogenesis [IMP]
- atrial septum secundum morphogenesis [IMP]
- bone development [IMP]
- chromatin modification [IDA]
- histone H3-K36 methylation [IDA]
- histone H4-K20 methylation [IDA]
- membranous septum morphogenesis [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- peptidyl-lysine methylation [IDA]
- positive regulation of isotype switching to IgA isotypes [IMP]
- regulation of double-strand break repair via nonhomologous end joining [IMP]
- regulation of establishment of protein localization [IMP]
- regulation of transcription, DNA-templated [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
SALL1
Gene Ontology Biological Process
- branching involved in ureteric bud morphogenesis [IMP]
- embryonic digestive tract development [ISO]
- embryonic digit morphogenesis [IMP, ISO]
- forelimb morphogenesis [IGI]
- heart development [ISO]
- hindlimb morphogenesis [IGI]
- inductive cell-cell signaling [IMP]
- kidney development [ISO]
- kidney epithelium development [IMP]
- limb development [ISO]
- mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis [IMP]
- mesenchymal to epithelial transition involved in metanephros morphogenesis [IMP]
- negative regulation of ectoderm development [IMP]
- negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [IMP]
- negative regulation of mesoderm development [IMP]
- negative regulation of smoothened signaling pathway [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP, ISO]
- neural tube closure [IGI]
- neural tube development [IGI]
- olfactory bulb development [IMP]
- olfactory bulb interneuron differentiation [IMP]
- olfactory bulb mitral cell layer development [ISO]
- olfactory nerve development [IMP]
- outer ear morphogenesis [ISO]
- positive regulation of Wnt signaling pathway [ISO]
- positive regulation of branching involved in ureteric bud morphogenesis [IMP]
- positive regulation of neuron differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of neural precursor cell proliferation [IMP]
- transcription from RNA polymerase II promoter [IDA]
- ureteric bud development [IMP]
- ureteric bud invasion [IMP]
- ventricular septum development [IGI, IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription coactivator activity [IDA]
- RNA polymerase II transcription factor binding [IPI]
- beta-catenin binding [ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [IDA]
- histone deacetylase activity [IMP]
- protein binding [IPI]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription coactivator activity [IDA]
- RNA polymerase II transcription factor binding [IPI]
- beta-catenin binding [ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [IDA]
- histone deacetylase activity [IMP]
- protein binding [IPI]
Gene Ontology Cellular Component
- NuRD complex [IDA]
- chromocenter [ISO]
- cytoplasm [ISO]
- heterochromatin [IDA, ISO]
- nucleus [IC, IDA, ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome.
Diverse histone modifications are catalysed and recognized by various specific proteins, establishing unique modification patterns that act as transcription signals. In particular, histone H3 trimethylation at lysine 36 (H3K36me3) is associated with actively transcribed regions and has been proposed to provide landmarks for continuing transcription; however, the control mechanisms and functions of H3K36me3 in higher eukaryotes are unknown. Here we ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| WHSC1 SALL1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID