WHSC1
Gene Ontology Biological Process
- atrial septum primum morphogenesis [IMP]
- atrial septum secundum morphogenesis [IMP]
- bone development [IMP]
- chromatin modification [IDA]
- histone H3-K36 methylation [IDA]
- histone H4-K20 methylation [IDA]
- membranous septum morphogenesis [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- peptidyl-lysine methylation [IDA]
- positive regulation of isotype switching to IgA isotypes [IMP]
- regulation of double-strand break repair via nonhomologous end joining [IMP]
- regulation of establishment of protein localization [IMP]
- regulation of transcription, DNA-templated [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
OGT
Gene Ontology Biological Process
- apoptotic process [ISO]
- cellular response to glucose stimulus [ISO]
- cellular response to lipopolysaccharide [ISO]
- cellular response to retinoic acid [ISO]
- circadian regulation of gene expression [IMP]
- glucosamine metabolic process [ISO]
- histone H3-K4 trimethylation [ISO]
- histone H4-K16 acetylation [ISO]
- histone H4-K5 acetylation [ISO]
- histone H4-K8 acetylation [ISO]
- intracellular distribution of mitochondria [ISO]
- negative regulation of cell death [ISO]
- negative regulation of cellular response to hypoxia [ISO]
- negative regulation of peptidyl-serine phosphorylation [ISO]
- negative regulation of peptidyl-threonine phosphorylation [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of protein targeting to membrane [ISO]
- negative regulation of protein ubiquitination [IDA]
- phosphatidylinositol-mediated signaling [ISO]
- positive regulation of catalytic activity [ISO]
- positive regulation of cell size [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of granulocyte differentiation [ISO]
- positive regulation of histone H3-K27 methylation [ISO]
- positive regulation of histone H3-K4 methylation [ISO]
- positive regulation of protein localization to nucleus [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of proteolysis [ISO]
- positive regulation of reactive oxygen species biosynthetic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein O-linked glycosylation [IDA, ISO, ISS, TAS]
- protein heterotrimerization [ISO]
- protein homotrimerization [ISO]
- regulation of Rac protein signal transduction [ISO]
- regulation of gluconeogenesis involved in cellular glucose homeostasis [IMP]
- regulation of glycolytic process [ISO]
- regulation of insulin receptor signaling pathway [ISO]
- response to insulin [ISO]
Gene Ontology Molecular Function- N-acetyltransferase activity [TAS]
- catalytic activity [ISS]
- enzyme activator activity [ISO]
- histone acetyltransferase activity (H4-K16 specific) [ISO]
- histone acetyltransferase activity (H4-K5 specific) [ISO]
- histone acetyltransferase activity (H4-K8 specific) [ISO]
- monosaccharide binding [ISO]
- peptide binding [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- protein N-acetylglucosaminyltransferase activity [ISO]
- protein O-GlcNAc transferase activity [IDA, IMP, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- transcription factor binding [ISO]
- N-acetyltransferase activity [TAS]
- catalytic activity [ISS]
- enzyme activator activity [ISO]
- histone acetyltransferase activity (H4-K16 specific) [ISO]
- histone acetyltransferase activity (H4-K5 specific) [ISO]
- histone acetyltransferase activity (H4-K8 specific) [ISO]
- monosaccharide binding [ISO]
- peptide binding [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- protein N-acetylglucosaminyltransferase activity [ISO]
- protein O-GlcNAc transferase activity [IDA, IMP, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- MLL5-L complex [ISO]
- cytoplasm [ISO, TAS]
- cytosol [ISO]
- euchromatin [ISO]
- histone acetyltransferase complex [ISO]
- intracellular [TAS]
- microtubule organizing center [ISO]
- mitochondrion [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleoplasm [ISO]
- nucleus [ISO, TAS]
- plasma membrane [ISO]
- zymogen granule [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome.
Diverse histone modifications are catalysed and recognized by various specific proteins, establishing unique modification patterns that act as transcription signals. In particular, histone H3 trimethylation at lysine 36 (H3K36me3) is associated with actively transcribed regions and has been proposed to provide landmarks for continuing transcription; however, the control mechanisms and functions of H3K36me3 in higher eukaryotes are unknown. Here we ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| WHSC1 OGT | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID