BAIT
RYR2
9330127I20Rik, RYR-2
ryanodine receptor 2, cardiac
GO Process (40)
GO Function (16)
GO Component (21)
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- Purkinje myocyte to ventricular cardiac muscle cell signaling [IMP]
- calcium ion transmembrane transport [IDA, IMP, ISO]
- calcium ion transport [IDA, IMP, IPI, ISO]
- calcium ion transport into cytosol [ISO]
- calcium-mediated signaling [IMP]
- calcium-mediated signaling using intracellular calcium source [ISO]
- canonical Wnt signaling pathway [IDA]
- cardiac muscle contraction [ISO]
- cardiac muscle hypertrophy [IMP]
- cellular calcium ion homeostasis [IMP]
- cellular response to caffeine [IDA, ISO]
- cytosolic calcium ion homeostasis [ISO]
- cytosolic calcium ion transport [IMP]
- detection of calcium ion [ISO]
- embryonic heart tube morphogenesis [IMP]
- establishment of protein localization to endoplasmic reticulum [ISO]
- ion transmembrane transport [ISO]
- left ventricular cardiac muscle tissue morphogenesis [IMP]
- manganese ion transmembrane transport [ISO]
- negative regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of calcium-transporting ATPase activity [ISO]
- positive regulation of heart rate [IMP]
- positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction [IMP]
- positive regulation of sequestering of calcium ion [ISO]
- positive regulation of the force of heart contraction [ISO]
- regulation of cardiac muscle contraction [ISO]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IGI]
- regulation of heart rate [IMP, ISO]
- release of sequestered calcium ion into cytosol [ISO]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA, IMP, ISO]
- response to caffeine [IDA, ISO]
- response to calcium ion [ISO]
- response to hypoxia [IDA]
- response to magnesium ion [ISO]
- response to muscle stretch [ISO]
- response to redox state [ISO]
- sarcoplasmic reticulum calcium ion transport [ISO]
- type B pancreatic cell apoptotic process [IMP, ISO]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function- calcium channel activity [IDA]
- calcium-induced calcium release activity [ISO]
- calcium-release channel activity [ISO]
- calmodulin binding [IDA, ISO]
- enzyme binding [IPI, ISO]
- identical protein binding [ISO]
- intracellular ligand-gated calcium channel activity [IDA]
- organic cyclic compound binding [IPI]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase binding [IPI]
- protein self-association [IMP]
- ryanodine-sensitive calcium-release channel activity [IDA, ISO]
- scaffold protein binding [ISO]
- suramin binding [ISO]
- calcium channel activity [IDA]
- calcium-induced calcium release activity [ISO]
- calcium-release channel activity [ISO]
- calmodulin binding [IDA, ISO]
- enzyme binding [IPI, ISO]
- identical protein binding [ISO]
- intracellular ligand-gated calcium channel activity [IDA]
- organic cyclic compound binding [IPI]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase binding [IPI]
- protein self-association [IMP]
- ryanodine-sensitive calcium-release channel activity [IDA, ISO]
- scaffold protein binding [ISO]
- suramin binding [ISO]
Gene Ontology Cellular Component
- A band [ISO]
- Z disc [IDA, ISO]
- calcium channel complex [IDA, ISO]
- cell [IMP]
- cytoplasm [ISO]
- cytosol [IMP]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [ISO]
- integral component of membrane [IC]
- intracellular [IGI]
- membrane [IDA, ISO]
- neuron projection [ISO]
- nuclear envelope [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- sarcolemma [ISO]
- sarcomere [IDA]
- sarcoplasmic reticulum [IDA, ISO]
- sarcoplasmic reticulum membrane [IDA, ISO]
- smooth endoplasmic reticulum [IDA]
Mus musculus
PREY
PSEN2
ALG-3, Ad4h, Alg3, PS-2, PS2, Psnl2, STM2
presenilin 2
GO Process (51)
GO Function (2)
GO Component (26)
Gene Ontology Biological Process
- Notch receptor processing [IBA]
- Notch signaling pathway [IGI]
- T cell activation involved in immune response [IGI]
- T cell receptor signaling pathway [IGI]
- amyloid precursor protein catabolic process [IBA]
- anagen [IGI]
- beta-amyloid metabolic process [IDA, IMP]
- brain morphogenesis [IGI]
- calcium ion transport [IPI]
- cardiac muscle contraction [IMP]
- cell fate specification [IGI]
- cellular protein metabolic process [IGI]
- dorsal/ventral neural tube patterning [IGI]
- embryo development [IGI]
- embryonic limb morphogenesis [IGI]
- endoplasmic reticulum calcium ion homeostasis [IGI]
- forebrain development [IGI]
- hair follicle development [IGI]
- hematopoietic progenitor cell differentiation [IGI]
- learning or memory [IGI]
- locomotion [IGI]
- lung alveolus development [IMP]
- membrane protein ectodomain proteolysis [IBA, ISO]
- memory [IGI]
- myeloid leukocyte differentiation [IGI]
- negative regulation of apoptotic process [IBA]
- negative regulation of apoptotic signaling pathway [IGI]
- negative regulation of epidermal growth factor-activated receptor activity [IMP]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- negative regulation of protein binding [IDA]
- negative regulation of protein complex assembly [IDA]
- negative regulation of protein phosphorylation [IGI]
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of ubiquitin-protein transferase activity [IMP]
- positive regulation of apoptotic process [IGI]
- positive regulation of catalytic activity [ISO]
- positive regulation of coagulation [IMP]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of receptor recycling [IMP]
- protein maturation [IGI]
- protein processing [IGI, ISO]
- protein transport [IGI]
- proteolysis [IGI]
- regulation of epidermal growth factor-activated receptor activity [IGI]
- regulation of protein binding [IGI]
- regulation of synaptic plasticity [IGI]
- skin morphogenesis [IMP]
- somitogenesis [IGI]
- thymus development [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- Z disc [IDA]
- apical plasma membrane [IBA]
- axon [IBA]
- cell [IGI]
- cell cortex [IBA]
- cell surface [IBA]
- centrosome [ISO]
- ciliary basal body [IDA]
- ciliary rootlet [IBA]
- cytosol [IDA]
- dendritic shaft [IBA]
- endoplasmic reticulum [IDA, IGI, ISO]
- growth cone [IBA]
- integral component of plasma membrane [IBA, ISO]
- kinetochore [ISO]
- lysosomal membrane [IBA]
- membrane [IDA, ISO]
- membrane raft [IBA]
- mitochondrial inner membrane [IBA]
- neuromuscular junction [IBA]
- neuronal cell body [IDA]
- nuclear inner membrane [ISO]
- nucleus [IBA]
- perinuclear region of cytoplasm [IBA]
- protein complex [ISO]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling.
Genetic studies of families with familial Alzheimer's disease have implicated presenilin 2 (PS2) in the pathogenesis of this disease. PS2 is ubiquitously expressed in various tissues including hearts. In this study, we examined cardiac phenotypes of PS2 knockout (PS2KO) mice to elucidate a role of PS2 in hearts. PS2KO mice developed normally with no evidence of cardiac hypertrophy and fibrosis. ... [more]
FASEB J. Dec. 01, 2005; 19(14);2069-71 [Pubmed: 16204356]
Throughput
- Low Throughput
Curated By
- BioGRID