PSEN2
Gene Ontology Biological Process
- Notch receptor processing [IBA]
- Notch signaling pathway [IGI]
- T cell activation involved in immune response [IGI]
- T cell receptor signaling pathway [IGI]
- amyloid precursor protein catabolic process [IBA]
- anagen [IGI]
- beta-amyloid metabolic process [IDA, IMP]
- brain morphogenesis [IGI]
- calcium ion transport [IPI]
- cardiac muscle contraction [IMP]
- cell fate specification [IGI]
- cellular protein metabolic process [IGI]
- dorsal/ventral neural tube patterning [IGI]
- embryo development [IGI]
- embryonic limb morphogenesis [IGI]
- endoplasmic reticulum calcium ion homeostasis [IGI]
- forebrain development [IGI]
- hair follicle development [IGI]
- hematopoietic progenitor cell differentiation [IGI]
- learning or memory [IGI]
- locomotion [IGI]
- lung alveolus development [IMP]
- membrane protein ectodomain proteolysis [IBA, ISO]
- memory [IGI]
- myeloid leukocyte differentiation [IGI]
- negative regulation of apoptotic process [IBA]
- negative regulation of apoptotic signaling pathway [IGI]
- negative regulation of epidermal growth factor-activated receptor activity [IMP]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- negative regulation of protein binding [IDA]
- negative regulation of protein complex assembly [IDA]
- negative regulation of protein phosphorylation [IGI]
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of ubiquitin-protein transferase activity [IMP]
- positive regulation of apoptotic process [IGI]
- positive regulation of catalytic activity [ISO]
- positive regulation of coagulation [IMP]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of receptor recycling [IMP]
- protein maturation [IGI]
- protein processing [IGI, ISO]
- protein transport [IGI]
- proteolysis [IGI]
- regulation of epidermal growth factor-activated receptor activity [IGI]
- regulation of protein binding [IGI]
- regulation of synaptic plasticity [IGI]
- skin morphogenesis [IMP]
- somitogenesis [IGI]
- thymus development [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- Z disc [IDA]
- apical plasma membrane [IBA]
- axon [IBA]
- cell [IGI]
- cell cortex [IBA]
- cell surface [IBA]
- centrosome [ISO]
- ciliary basal body [IDA]
- ciliary rootlet [IBA]
- cytosol [IDA]
- dendritic shaft [IBA]
- endoplasmic reticulum [IDA, IGI, ISO]
- growth cone [IBA]
- integral component of plasma membrane [IBA, ISO]
- kinetochore [ISO]
- lysosomal membrane [IBA]
- membrane [IDA, ISO]
- membrane raft [IBA]
- mitochondrial inner membrane [IBA]
- neuromuscular junction [IBA]
- neuronal cell body [IDA]
- nuclear inner membrane [ISO]
- nucleus [IBA]
- perinuclear region of cytoplasm [IBA]
- protein complex [ISO]
SRI
Gene Ontology Biological Process
- calcium ion transport [IPI]
- cytoplasmic sequestering of transcription factor [IMP]
- negative regulation of heart rate [ISO]
- negative regulation of ryanodine-sensitive calcium-release channel activity [ISO]
- negative regulation of transcription regulatory region DNA binding [IMP]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- positive regulation of release of sequestered calcium ion into cytosol [IMP]
- proteolysis [IBA]
- regulation of calcium ion transport [ISO]
- regulation of cardiac muscle cell contraction [ISO]
- regulation of cell communication by electrical coupling involved in cardiac conduction [ISO]
- regulation of high voltage-gated calcium channel activity [ISO]
- regulation of relaxation of muscle [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISO]
- Z disc [IDA, ISO]
- axon [ISO]
- axon terminus [ISO]
- cell [IMP]
- chromaffin granule membrane [ISO]
- cytoplasm [IMP, ISO]
- cytosol [ISO]
- dendritic spine neck [ISO]
- endoplasmic reticulum membrane [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IDA]
- membrane [ISO]
- mitochondrion [ISO]
- nucleoplasm [ISO]
- plasma membrane [IDA, ISO]
- smooth endoplasmic reticulum [ISO]
- vesicle [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling.
Genetic studies of families with familial Alzheimer's disease have implicated presenilin 2 (PS2) in the pathogenesis of this disease. PS2 is ubiquitously expressed in various tissues including hearts. In this study, we examined cardiac phenotypes of PS2 knockout (PS2KO) mice to elucidate a role of PS2 in hearts. PS2KO mice developed normally with no evidence of cardiac hypertrophy and fibrosis. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID