OLIG2
Gene Ontology Biological Process
- myelination [IMP]
- negative regulation of neuron differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- nervous system development [IDA]
- neuron fate commitment [IMP]
- oligodendrocyte differentiation [IMP]
- positive regulation of oligodendrocyte differentiation [IGI]
- regulation of transcription, DNA-templated [IDA, ISS]
- spinal cord motor neuron differentiation [IMP]
- spinal cord oligodendrocyte cell differentiation [IGI]
- spinal cord oligodendrocyte cell fate specification [IDA]
- thalamus development [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
NEUROG2
Gene Ontology Biological Process
- axon guidance [IMP]
- cell fate commitment [IGI]
- cell maturation [IMP]
- central nervous system neuron development [IGI, IMP]
- forebrain development [IMP]
- neurogenesis [IDA]
- neuron differentiation [IMP]
- neuron migration [IMP]
- positive regulation of neuron differentiation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells.
Spinal motor neurons and oligodendrocytes are generated sequentially from a common pool of progenitors termed pMN cells. Olig2 is a bHLH-class transcription factor in pMN cells, but it has remained unclear how its transcriptional activity is modulated to first produce motor neurons and then oligodendrocytes. Previous studies have shown that Olig2 primes pMN cells to become motor neurons by triggering ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID