BTG2
Gene Ontology Biological Process
- anterior/posterior pattern specification [IMP]
- associative learning [IMP]
- cellular response to DNA damage stimulus [ISO]
- central nervous system neuron development [IMP]
- dentate gyrus development [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of neural precursor cell proliferation [IMP]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of translation [ISO]
- neuron differentiation [ISO]
- neuron projection development [ISO]
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [ISO]
- protein methylation [IDA]
- skeletal muscle cell differentiation [IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SMAD9
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IGI]
- Mullerian duct regression [ISO]
- bone development [IGI]
- cartilage development [IGI]
- cellular response to organic cyclic compound [IDA]
- hindbrain development [IMP]
- midbrain development [IMP]
- positive regulation of cell differentiation [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein phosphorylation [IDA]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling.
Btg2 is a primary p53 transcriptional target gene which may function as a coactivator-corepressor and/or an adaptor molecule that modulates the activities of its interacting proteins. We have generated Btg2-null mice to elucidate the in vivo function of Btg2. Btg2-null mice are viable and fertile but exhibit posterior homeotic transformations of the axial vertebrae in a dose-dependent manner. Consistent with ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID