SOD2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ALD4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Superoxide triggers an acid burst in Saccharomyces cerevisiae to condition the environment of glucose-starved cells.
While yeast cells grown in abundant glucose tend to acidify their extracellular environment, they raise the pH of the environment when starved for glucose or when grown strictly with non-fermentable carbon sources. Following prolonged periods in this alkaline phase, Saccharomyces cerevisiae cells will switch to producing acid. The mechanisms and rationale for this acid burst were unknown. Herein we provide ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: redox state (APO:0000218)
Additional Notes
- ALD4 deletion reverses acid burst response of sod2 mutant grown in glycerol
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SOD2 ALD4 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1241 | BioGRID | 2125649 |
Curated By
- BioGRID