BLOC1S3
Gene Ontology Biological Process
- anterograde axon cargo transport [IMP]
- anterograde synaptic vesicle transport [IMP]
- blood coagulation [IMP]
- developmental pigmentation [IMP]
- endosome to melanosome transport [ISO]
- eye development [ISO]
- melanosome organization [IMP]
- melanosome transport [ISO]
- neuron projection development [NAS]
- pigmentation [IMP, ISO]
- platelet activation [ISO]
- platelet dense granule organization [IMP]
- positive regulation of natural killer cell activation [IMP]
- response to drug [IMP]
- secretion of lysosomal enzymes [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BLOC1S6
Gene Ontology Biological Process
- anterograde axon cargo transport [IMP]
- anterograde synaptic vesicle transport [IMP]
- blood coagulation [IMP]
- endosome to melanosome transport [ISO]
- melanocyte differentiation [IMP]
- melanosome transport [ISO]
- membrane fusion [IPI]
- neuron projection development [IMP]
- pigmentation [IMP]
- positive regulation of natural killer cell activation [IMP]
- positive regulation of pigment cell differentiation [ISO]
- secretion of lysosomal enzymes [IMP]
- vesicle docking involved in exocytosis [TAS]
- vesicle fusion [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Reduced pigmentation (rp), a mouse model of Hermansky-Pudlak syndrome, encodes a novel component of the BLOC-1 complex.
Hermansky-Pudlak syndrome (HPS), a disorder of organelle biogenesis, affects lysosomes, melanosomes, and platelet dense bodies. Seven genes cause HPS in humans (HPS1-HPS7) and at least 15 nonallelic mutations cause HPS in mice. Where their function is known, the HPS proteins participate in protein trafficking and vesicle docking/fusion events during organelle biogenesis. HPS-associated genes participate in at least 4 distinct protein ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BLOC1S3 BLOC1S6 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | Low | - | BioGRID | - |
Curated By
- BioGRID