BAIT
LIN7C
9130007B12Rik, AI303698, AU019331, AW125731, D2Ertd520e, LIN-7-C, LIN-7C, MALS-3, Veli3, RP23-207C2.1
lin-7 homolog C (C. elegans)
GO Process (2)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NRXN1
1700062G21Rik, 9330127H16Rik, A230068P09Rik, mKIAA0578
neurexin I
GO Process (22)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- adult behavior [IMP, ISO]
- gephyrin clustering [IDA]
- learning [IMP, ISO]
- neuroligin clustering [IDA]
- neuromuscular process controlling balance [IMP]
- neurotransmitter secretion [IGI, TAS]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- positive regulation of synapse assembly [IGI]
- positive regulation of synapse maturation [IDA]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- postsynaptic density protein 95 clustering [IDA]
- postsynaptic membrane assembly [IDA]
- prepulse inhibition [IMP]
- protein heterotetramerization [ISO]
- regulation of grooming behavior [IMP]
- regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- social behavior [ISO]
- synapse assembly [IGI]
- synaptic transmission [IGI]
- vesicle docking involved in exocytosis [ISO]
- vocal learning [ISO]
- vocalization behavior [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex.
Synapses are highly specialized intercellular junctions organized by adhesive and scaffolding molecules that align presynaptic vesicular release with postsynaptic neurotransmitter receptors. The MALS/Veli-CASK-Mint-1 complex of PDZ proteins occurs on both sides of the synapse and has the potential to link transsynaptic adhesion molecules to the cytoskeleton. In this study, we purified the MALS protein complex from brain and found liprin-alpha ... [more]
J. Cell Biol. Sep. 26, 2005; 170(7);1127-34 [Pubmed: 16186258]
Throughput
- Low Throughput
Curated By
- BioGRID