An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex.

Olsen O, Moore KA, Fukata M, Kazuta T, Trinidad JC, Kauer FW, Streuli M, Misawa H, Burlingame AL, Nicoll RA, Bredt DS

Synapses are highly specialized intercellular junctions organized by adhesive and scaffolding molecules that align presynaptic vesicular release with postsynaptic neurotransmitter receptors. The MALS/Veli-CASK-Mint-1 complex of PDZ proteins occurs on both sides of the synapse and has the potential to link transsynaptic adhesion molecules to the cytoskeleton. In this study, we purified the MALS protein complex from brain and found liprin-alpha ... [more]

J. Cell Biol. Sep. 26, 2005; 170(7);1127-34 [Pubmed: 16186258]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

LIN7C

Gene Ontology Biological Process

Gene Ontology Molecular Function

L27 domain binding [ISO]PDZ domain binding [ISO]cytoskeletal protein binding [ISO]protein binding [IPI]protein domain specific binding [ISO]

Gene Ontology Cellular Component

CASKIN1