BAIT
LIN7C
9130007B12Rik, AI303698, AU019331, AW125731, D2Ertd520e, LIN-7-C, LIN-7C, MALS-3, Veli3, RP23-207C2.1
lin-7 homolog C (C. elegans)
GO Process (2)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DLG1
B130052P05Rik, Dlgh1, E-dlg/SAP97, SAP-97, SAP97, mKIAA4187
discs, large homolog 1 (Drosophila)
GO Process (40)
GO Function (13)
GO Component (32)
Gene Ontology Biological Process
- T cell activation [IMP]
- T cell cytokine production [IMP]
- actin filament organization [ISO]
- activation of protein kinase activity [IMP]
- amyloid precursor protein metabolic process [IGI]
- branching involved in ureteric bud morphogenesis [IMP]
- cortical actin cytoskeleton organization [ISO]
- embryonic skeletal system morphogenesis [IMP]
- endothelial cell proliferation [ISO]
- establishment or maintenance of epithelial cell apical/basal polarity [IBA]
- hard palate development [IMP]
- immunological synapse formation [IMP]
- lens development in camera-type eye [IMP]
- membrane raft organization [IMP]
- negative regulation of T cell proliferation [IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of protein kinase B signaling [IMP]
- nucleotide phosphorylation [IBA]
- peristalsis [IMP]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of developmental growth [TAS]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of multicellular organism growth [TAS]
- positive regulation of potassium ion transport [ISO]
- protein localization [IGI, IMP]
- protein localization to plasma membrane [ISO]
- receptor clustering [IBA]
- receptor localization to synapse [IBA]
- regulation of membrane potential [IGI, ISO]
- regulation of myelination [IMP]
- regulation of protein localization [ISO]
- reproductive structure development [IMP]
- single organismal cell-cell adhesion [ISO]
- smooth muscle tissue development [IMP]
- synaptic transmission [IBA]
- tight junction assembly [ISO]
- tissue morphogenesis [IMP]
- ureteric bud development [IMP]
Gene Ontology Molecular Function- L27 domain binding [ISO]
- PDZ domain binding [ISO]
- guanylate kinase activity [IBA]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IBA, ISO]
- kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphatase binding [ISO]
- potassium channel regulator activity [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex scaffold [IMP]
- protein kinase binding [ISO]
- L27 domain binding [ISO]
- PDZ domain binding [ISO]
- guanylate kinase activity [IBA]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IBA, ISO]
- kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphatase binding [ISO]
- potassium channel regulator activity [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex scaffold [IMP]
- protein kinase binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- MPP7-DLG1-LIN7 complex [ISO]
- T-tubule [ISO]
- basal lamina [IDA]
- basal plasma membrane [ISO]
- basolateral plasma membrane [IDA, ISO, TAS]
- cell junction [IDA, ISO]
- cell projection membrane [IDA]
- cell-cell adherens junction [TAS]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- cytoplasmic side of plasma membrane [ISO]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- immunological synapse [IDA]
- ionotropic glutamate receptor complex [IBA]
- lateral loop [IDA]
- lateral plasma membrane [IDA]
- membrane raft [IDA]
- microtubule [ISO]
- myelin sheath abaxonal region [IDA]
- neuromuscular junction [IDA]
- neuron projection [ISO]
- node of Ranvier [IDA]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA]
- presynaptic membrane [ISO]
- synapse [IDA]
- tight junction [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex.
Synapses are highly specialized intercellular junctions organized by adhesive and scaffolding molecules that align presynaptic vesicular release with postsynaptic neurotransmitter receptors. The MALS/Veli-CASK-Mint-1 complex of PDZ proteins occurs on both sides of the synapse and has the potential to link transsynaptic adhesion molecules to the cytoskeleton. In this study, we purified the MALS protein complex from brain and found liprin-alpha ... [more]
J. Cell Biol. Sep. 26, 2005; 170(7);1127-34 [Pubmed: 16186258]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LIN7C DLG1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.829 | BioGRID | 2668604 |
Curated By
- BioGRID