TRAF2
Gene Ontology Biological Process
- activation of NF-kappaB-inducing kinase activity [ISO]
- cellular protein complex assembly [IDA]
- cellular response to nitric oxide [IMP]
- negative regulation of apoptotic process [NAS]
- negative regulation of glial cell apoptotic process [ISO]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of NF-kappaB transcription factor activity [IMP, ISO]
- positive regulation of T cell cytokine production [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- positive regulation of interleukin-2 production [ISO]
- positive regulation of protein homodimerization activity [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- programmed necrotic cell death [IMP]
- protein K63-linked ubiquitination [ISO]
- protein autoubiquitination [ISO]
- protein catabolic process [IMP]
- protein complex assembly [ISO]
- protein heterooligomerization [ISO]
- protein homotrimerization [ISO]
- regulation of JNK cascade [IDA]
- regulation of apoptotic process [ISO]
- regulation of immunoglobulin secretion [IMP]
- signal transduction [IDA]
- tumor necrosis factor-mediated signaling pathway [ISO]
Gene Ontology Molecular Function- CD40 receptor binding [IPI]
- enzyme binding [ISO]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- sphingolipid binding [ISO]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- CD40 receptor binding [IPI]
- enzyme binding [ISO]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- sphingolipid binding [ISO]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO]
Gene Ontology Cellular Component
TIFA
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
T2BP, a novel TRAF2 binding protein, can activate NF-kappaB and AP-1 without TNF stimulation.
TRAF2 is a key molecule involved in TNF signaling, which is crucial for the regulation of inflammatory processes. We have identified a novel TRAF2 binding protein, designated as T2BP (TRAF2 binding protein), by a mammalian two-hybrid screening approach. T2BP is a relatively small protein of 184 amino acids, which includes a forkhead-associated domain, the phosphopeptide binding motif. The interaction domain ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TIFA TRAF2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID