GATA6
Gene Ontology Biological Process
- Clara cell differentiation [IGI]
- Type II pneumocyte differentiation [IGI]
- cardiac muscle cell differentiation [IGI, IMP]
- cardiac muscle hypertrophy in response to stress [IMP]
- cardiac muscle tissue development [IGI]
- cardiac vascular smooth muscle cell differentiation [ISO]
- cellular response to BMP stimulus [IDA]
- cellular response to gonadotropin stimulus [IDA]
- cellular response to hypoxia [ISO]
- endodermal cell differentiation [IMP]
- endodermal cell fate determination [IDA]
- epithelial cell differentiation [IMP]
- in utero embryonic development [IMP]
- intestinal epithelial cell differentiation [ISO]
- liver development [IMP]
- lung saccule development [IGI]
- negative regulation of apoptotic process [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of transforming growth factor beta1 production [ISO]
- negative regulation of transforming growth factor beta2 production [ISO]
- organ formation [IMP]
- outflow tract septum morphogenesis [ISO]
- pancreas development [IMP]
- pancreatic A cell differentiation [IMP]
- phospholipid metabolic process [IGI]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cardiac muscle cell proliferation [IGI]
- positive regulation of cell cycle arrest [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of gene expression [IGI]
- response to drug [ISO]
- response to estrogen [IDA]
- response to growth factor [ISO]
- smooth muscle cell differentiation [ISO]
- transcription from RNA polymerase II promoter [IDA, ISO]
- tube morphogenesis [IGI]
- type B pancreatic cell differentiation [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- enhancer sequence-specific DNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- enhancer sequence-specific DNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
TTF1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression.
GATA-6, a member of the GATA family of zinc finger domain containing transcription factors, is expressed in endodermally derived tissues including the lung, where GATA-6 influences the transcription of target genes, TTF-1, and surfactant proteins. Whereas GATA-6 did not directly alter expression of sp-C constructs in HeLa cells, GATA-6 synergistically activated sp-C gene transcription when co-expressed with TTF-1, supporting the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID