NCOR1
Gene Ontology Biological Process
- CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [IMP]
- cholesterol homeostasis [IMP]
- circadian regulation of gene expression [IGI]
- definitive erythrocyte differentiation [IMP]
- negative regulation of JNK cascade [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of phosphatidylinositol 3-kinase signaling [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI, IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP, ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of histone deacetylation [IDA]
- regulation of catalytic activity [IMP]
- regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of histone deacetylation [IMP]
- regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of multicellular organism growth [IGI]
- regulation of transcription from RNA polymerase II promoter [IGI]
- spindle assembly [ISO]
- thalamus development [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II regulatory region DNA binding [ISO]
- chromatin binding [ISO]
- estrogen receptor binding [ISO]
- histone deacetylase binding [ISO]
- histone deacetylase regulator activity [IDA, IMP]
- nuclear hormone receptor binding [ISO]
- peroxisome proliferator activated receptor binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- retinoic acid receptor binding [IDA, ISO]
- retinoid X receptor binding [IDA, ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- thyroid hormone receptor binding [IDA, IPI]
- transcription corepressor activity [IGI, ISO]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II regulatory region DNA binding [ISO]
- chromatin binding [ISO]
- estrogen receptor binding [ISO]
- histone deacetylase binding [ISO]
- histone deacetylase regulator activity [IDA, IMP]
- nuclear hormone receptor binding [ISO]
- peroxisome proliferator activated receptor binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- retinoic acid receptor binding [IDA, ISO]
- retinoid X receptor binding [IDA, ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- thyroid hormone receptor binding [IDA, IPI]
- transcription corepressor activity [IGI, ISO]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
PATZ1
Gene Ontology Biological Process
- T cell differentiation [IDA]
- male gonad development [IMP]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of gene expression [IDA]
- regulation of transcription, DNA-templated [IPI]
- spermatogenesis [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IDA]
- protein binding [IPI]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IDA]
- protein binding [IPI]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR.
Coreceptor expression is tightly regulated during thymocyte development. Deletion of specific Cd8 enhancers leads to variegated expression of CD8alphabeta heterodimers in double-positive thymocytes. Here we show CD8 variegation is correlated with an epigenetic 'off' state, linking Cd8 enhancer function with chromatin remodeling of the adjacent genes Cd8a and Cd8b1 (Cd8). The zinc finger protein MAZR bound the Cd8 enhancer and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID