HCN1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PEX5L
Gene Ontology Biological Process
- cation transmembrane transport [ISO]
- cation transport [ISO]
- maintenance of protein location [IDA]
- positive regulation of corticotropin secretion [ISO]
- protein import into peroxisome matrix [IBA]
- protein import into peroxisome matrix, docking [IBA]
- regulated secretory pathway [ISO]
- regulation of cAMP-mediated signaling [ISO]
- regulation of membrane potential [IDA, IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction.
Hyperpolarization-activated cation currents (I(h)) are carried by channels encoded by a family of four genes (HCN1-4) that are differentially expressed within the brain in specific cellular and subcellular compartments. HCN1 shows a high level of expression in apical dendrites of cortical pyramidal neurons and in presynaptic terminals of cerebellar basket cells, structures with a high density of I(h). Expression of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PEX5L HCN1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2343582 | |
| HCN1 PEX5L | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2340021 |
Curated By
- BioGRID