BMI1
Gene Ontology Biological Process
- DNA methylation [IMP]
- brain development [IMP]
- cellular process [TAS]
- embryonic skeletal system development [IGI]
- embryonic skeletal system morphogenesis [IGI]
- histone acetylation [IGI]
- histone ubiquitination [IDA]
- humoral immune response [IMP]
- in utero embryonic development [IGI]
- negative regulation of apoptotic signaling pathway [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- positive regulation of B cell proliferation [IMP]
- positive regulation of immature T cell proliferation in thymus [IMP]
- regulation of catalytic activity [IDA]
- rostrocaudal neural tube patterning [IMP]
- skeletal system development [IMP]
- somatic stem cell division [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GATA6
Gene Ontology Biological Process
- Clara cell differentiation [IGI]
- Type II pneumocyte differentiation [IGI]
- cardiac muscle cell differentiation [IGI, IMP]
- cardiac muscle hypertrophy in response to stress [IMP]
- cardiac muscle tissue development [IGI]
- cardiac vascular smooth muscle cell differentiation [ISO]
- cellular response to BMP stimulus [IDA]
- cellular response to gonadotropin stimulus [IDA]
- cellular response to hypoxia [ISO]
- endodermal cell differentiation [IMP]
- endodermal cell fate determination [IDA]
- epithelial cell differentiation [IMP]
- in utero embryonic development [IMP]
- intestinal epithelial cell differentiation [ISO]
- liver development [IMP]
- lung saccule development [IGI]
- negative regulation of apoptotic process [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of transforming growth factor beta1 production [ISO]
- negative regulation of transforming growth factor beta2 production [ISO]
- organ formation [IMP]
- outflow tract septum morphogenesis [ISO]
- pancreas development [IMP]
- pancreatic A cell differentiation [IMP]
- phospholipid metabolic process [IGI]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cardiac muscle cell proliferation [IGI]
- positive regulation of cell cycle arrest [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of gene expression [IGI]
- response to drug [ISO]
- response to estrogen [IDA]
- response to growth factor [ISO]
- smooth muscle cell differentiation [ISO]
- transcription from RNA polymerase II promoter [IDA, ISO]
- tube morphogenesis [IGI]
- type B pancreatic cell differentiation [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- enhancer sequence-specific DNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- enhancer sequence-specific DNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development.
The transcription factors Nanog and Gata6 are critical to specify the epiblast versus primitive endoderm (PrE) lineages. However, little is known about the mechanisms that regulate the protein stability and activity of these factors in the developing embryo. Here we uncover an early developmental function for the Polycomb group member Bmi1 in supporting PrE lineage formation through Gata6 protein stabilization. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GATA6 BMI1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID